典型文献
Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient Tumor Targeted siRNA Delivery
文献摘要：
RNA interference(RNAi),known for the highly efficient targeted gene silencing,has been demonstrated to be a promising means for cancer treatment.Meanwhile,an effective approach for siRNA delivery is urgently needed to meet the needs for its clinical application.Herein,we constructed a polymeric vector labeled with superparamagnetic iron oxide(SPIO)for magnetic resonance imaging(MRI)visible siRNA delivery.EGFR antibody was also modified to the surface of nanodrug to enhance the delivery effect.Our results showed that the vector exhibited great siRNA complexation ability and mediated an increased endocytosis of siRNA without obvious cytotoxicity.Besides,both in vitro and in vivo studies evidenced the vector could effectively deliver siRNA into tumor cells,exert highly interfering effect,and show potent MR imaging capacity.The study provides a promising MRI-visible and EGFR targeting delivery system to improve RNAi efficacy for cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Rong-Ze Wang;Si Huang;Qiao-Yun Zhang;Xing-Su Yu;Ke-Ze Hong;Jian-Rong Cao;Hong Xiao;Yong Wang;Xin-Tao Shuai
作者机构：
College of Chemistry and Materials Science,Jinan University,Guangzhou 510632,China;Department of Reproductive Medical Center,Guangdong Women and Children Hospital,Guangzhou511400,China;Nanomedicine Research Center,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China
文献出处：
引用格式：
[1]Rong-Ze Wang;Si Huang;Qiao-Yun Zhang;Xing-Su Yu;Ke-Ze Hong;Jian-Rong Cao;Hong Xiao;Yong Wang;Xin-Tao Shuai-.Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient Tumor Targeted siRNA Delivery)[J].高分子科学（英文版）,2022(09):1071-1079
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Construction,Magnetic,Resonance,Imaging,Visible,Polymeric,Vector,Efficient,Tumor,Targeted,siRNA,Delivery,interference,RNAi,known,highly,efficient,targeted,gene,silencing,has,been,demonstrated,promising,means,cancer,treatment,Meanwhile,approach,delivery,urgently,needed,meet,needs,its,clinical,application,Herein,constructed,polymeric,vector,labeled,superparamagnetic,iron,oxide,SPIO,resonance,imaging,visible,EGFR,antibody,was,also,modified,surface,nanodrug,enhance,Our,results,showed,that,exhibited,great,complexation,ability,mediated,increased,endocytosis,without,obvious,cytotoxicity,Besides,both,vitro,vivo,studies,evidenced,could,effectively,into,tumor,cells,exert,interfering,potent,capacity,study,provides,targeting,system,improve,efficacy,therapy
AB值：
0.699667
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