Hepatic malignancy is a major indication for liver transplantation;however,post-transplant cancer recurrence is an emerging clinical challenge affecting long-term outcomes.Pre-transplant tumor biology,staging,and post-transplant immunosuppression regimens have been elucidated as risk factors for recur-rent liver cancer.However,increasing evidence indicates that hepatic ischemia and reperfusion(IR)injury to allografts are crucial to providing a favorable immunologic microenvironment for cancer cell invasiveness and metastasis after liver transplantation.The association of severe graft injury in marginal grafts,such as small-for-size or fatty grafts,with lower recurrence-free survival rates in living donor liver transplantations,substantiates the correlation between hepatic IR injury and cancer recurrence.IR has been demonstrated to trigger intrahepatic immunological microenvironment remodeling,including pro-inflammatory responses exacerbating graft injury and anti-inflammatory responses promoting tissue repair.However,the role of regional immunity in post-transplant cancer recurrence is not comprehen-sively understood.This review describes the up-to-date evidence of the intrahepatic humoral microenvi-ronment and regional regulatory immunological microenvironment induced by IR injury,as well as their roles in cancer recurrence after liver transplantation.A comprehensive understanding of regional immu-nity will provide novel precise diagnostic,therapeutic,and prognostic strategies for post-transplant can-cer recurrence.

Jiang Liu;Chung Mau Lo;Kwan Man

Hepatopancreatobiliary Center,Beijing Tsinghua Changgung Hospital,Tsinghua University,Beijing 102218,China;Department of Surgery,HKU-Shenzhen Hospital&LKS Faculty of Medicine,The University of Hong Kong,Hong Kong 999077,China

工程（英文）

[1]Jiang Liu;Chung Mau Lo;Kwan Man-.Role of Intrahepatic Regional Immunity in Post-Transplant Cancer Recurrence)[J].工程（英文）,2022(03):57-64

microenvi

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