典型文献
A Rhein-Based Rh(Ⅲ)Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO
文献摘要：
Metallodrugs with fine-tuned coordination between metals and bioactive ligands can achieve cytotoxic effects in cancer therapy and have been considered as a new approach for drug design.However,it has yet to be elucidated whether these metallodrugs target epi-transcriptomic proteins for gene expression regulation.This report describes a rhein-based Rh(Ⅲ)-arene complex,Rh1,that exhibited promising antiproliferative effects in several tumor cell lines.Rh1 induced cell death through the autophagy,cell cycle arrest,and ac-cumulation of intracellular reactive oxygen species(ROS).In addition,Rh1 upregulated the global N6-methyladenosine(m6A)levels in A549 cells in the fat mass-and obesity-associated protein(FTO)-dependent manner.Collectively,the metal-based FTO inhibitor Rh1 effectively suppressed tumor cell proliferation and modulated the abundance of cellular m6A,highlighting the potential of met-al-based agents to target and regulate epitranscriptomics for tumor suppression.
文献关键词：
中图分类号：
作者姓名：
Lu Liu;Yaqiong Kong;Liang He;Xiuxiu Wang;Meng-Meng Wang;Hongjiao Xu;Cai-Guang Yang;Zhi Su;Jing Zhao;Zong-Wan Mao;Yue Huang;Hong-Ke Liu
作者机构：
School of Chemistry and Materials Science,Nanjing Normal University,Nanjing,Jiangsu 210023,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;School of Chemistry,Sun Yat-Sen University,Guangzhou,Guangdong 510275,China;School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,Jiangsu 210023,China;School of Pharmaceutical Science and Technology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang 310024,China
文献出处：
引用格式：
[1]Lu Liu;Yaqiong Kong;Liang He;Xiuxiu Wang;Meng-Meng Wang;Hongjiao Xu;Cai-Guang Yang;Zhi Su;Jing Zhao;Zong-Wan Mao;Yue Huang;Hong-Ke Liu-.A Rhein-Based Rh(Ⅲ)Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO)[J].中国化学（英文版）,2022(10):1156-1164
A类：
Arene,Proliferative,Demethylase,Metallodrugs,metallodrugs,epitranscriptomics
B类：
Rhein,Based,Complex,Anti,tumor,Cell,Activity,Inhibits,FTO,fine,tuned,coordination,between,metals,bioactive,ligands,achieve,cytotoxic,effects,cancer,therapy,have,been,considered,new,approach,design,However,has,yet,elucidated,whether,these,target,proteins,gene,expression,regulation,This,report,describes,rhein,arene,complex,Rh1,that,exhibited,promising,antiproliferative,several,lines,induced,death,through,autophagy,cycle,arrest,cumulation,intracellular,reactive,oxygen,species,ROS,addition,upregulated,global,N6,methyladenosine,m6A,levels,A549,cells,fat,mass,obesity,associated,dependent,manner,Collectively,inhibitor,effectively,suppressed,proliferation,modulated,abundance,highlighting,potential,agents,suppression
AB值：
0.612841
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