典型文献
Nanocomposites Facilitate the Removal of Aβ Fibrils for Neuroprotection
文献摘要：
Accumulation ofβ-amyloid(Aβ)fibrils in the brain is one of the main culprits in Alzheimer's disease(AD)progression,which initiates the neuronal damage and subsequent neurodegeneration.Various anti-Aβ agents have shown the potentials to dissociate Aβ fibrils.However,these approaches can't facilitate the removal of Aβ fibrils,resulting in a disappointing therapeutic effect.Herein,we demonstrate an integrated polymer nanocomposite(NP-GLVFF-IgG)that can dissociate Aβ fibrils into fragments and activate microglia to remove the fragments via Fc receptors-mediated phagocytosis.NP-GLVFF-IgG is constructed by an albumin/polymer hybrid nanoparticle with Gly-Leu-Val-Phe-Phe(GLVFF)peptides and Immunoglobulin G(IgG)molecules on the surface.In this design,NP-GLVFF-IgG achieves to dissociate the Aβfibrils by the strong hydrogen-bonding interactions between Aβfibrils and GLVFF peptides.Then,NP-GLVFF-IgG activates the microglial phagocytosis,thereby achieving an enhanced phagocytic removal of Aβ fibrils for neuroprotection.Moreover,NP-GLVFF-IgG achieves to trigger the effective removal of Aβ fibrils even under inflammatory condition that usually suppressed phagocytosis.Therefore,NP-GLVFF-IgG has great potential as a novel therapeutic platform for effective AD therapy.
文献关键词：
中图分类号：
作者姓名：
CHAI Jingshan;LI Qiushi;ZHAO Yu;LIU Yang
作者机构：
Key Laboratory of Functional Polymer Materials,Ministry of Education,State Key Laboratory of Medicinal Chemical Biology,College of Chemistry,Nankai University,Tianjin 300071,P.R.China
文献出处：
引用格式：
[1]CHAI Jingshan;LI Qiushi;ZHAO Yu;LIU Yang-.Nanocomposites Facilitate the Removal of Aβ Fibrils for Neuroprotection)[J].高等学校化学研究（英文版）,2022(02):522-528
A类：
Facilitate,Fibrils,GLVFF
B类：
Nanocomposites,Removal,Neuroprotection,Accumulation,amyloid,fibrils,brain,one,main,culprits,Alzheimer,disease,AD,progression,which,initiates,neuronal,damage,subsequent,neurodegeneration,Various,anti,agents,have,shown,potentials,dissociate,However,these,approaches,can,facilitate,removal,resulting,disappointing,therapeutic,Herein,demonstrate,integrated,polymer,nanocomposite,NP,IgG,that,into,fragments,remove,via,Fc,receptors,mediated,phagocytosis,constructed,albumin,hybrid,nanoparticle,Gly,Leu,Val,Phe,peptides,Immunoglobulin,molecules,surface,In,this,design,achieves,strong,hydrogen,bonding,interactions,between,Then,activates,microglial,thereby,achieving,enhanced,phagocytic,neuroprotection,Moreover,trigger,effective,even,under,inflammatory,condition,usually,suppressed,Therefore,has,great,novel,platform,therapy
AB值：
0.544113
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
