典型文献
Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma
文献摘要：
Traditional cancer treatments have disadvantages of large trauma area and toxic side effects while killing cancer cells.Peptide-targeted sonodynamic therapy(SDT)can effectively improve specificity of cancer treatment and overcome the problem of low tissue penetration depth caused by a photo-driven therapy.Herein,we developed a porphyrin-based sonosensitizer with a water-soluble polymer as a biological carrier and a cRGD peptide for tumor targeting,which constituted a nano sonosensitizer(T-cRGD NPs)for fluorescence imaging-guided sonodynamic therapy.A comparable sonosensitizer(T-PEG NPs)without the targeting unit was also prepared for illustration of therapeutic performance.Attribute to the role of peptide targeting,T-cRGD NPs can accumulate and enter tumor cells for fluorescence imaging and show a superior SDT effect than T-PEG NPs in vitro.The imaging in vivo reveals that T-cRGD NPs can enrich in tumor tissues within 14 h with a good biocompatibility.
文献关键词：
中图分类号：
作者姓名：
Mei-Yu Jiang;Jia-Sheng Wu;Wei-Min Liu;Hao-Hui Ren;Xin Wang;Peng-Fei Wang
作者机构：
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China;School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Mei-Yu Jiang;Jia-Sheng Wu;Wei-Min Liu;Hao-Hui Ren;Xin Wang;Peng-Fei Wang-.Porphyrin-based Nanosonosensitizers Combined with Targeting Peptides for Sonodynamic Therapy of Glioma)[J].高分子科学（英文版）,2022(09):1120-1128
A类：
Nanosonosensitizers
B类：
Porphyrin,Combined,Targeting,Peptides,Sonodynamic,Therapy,Glioma,Traditional,cancer,treatments,have,disadvantages,large,trauma,area,toxic,side,effects,while,killing,cells,targeted,sonodynamic,therapy,SDT,effectively,improve,specificity,overcome,problem,low,penetration,depth,caused,by,photo,driven,Herein,we,developed,porphyrin,water,soluble,polymer,biological,carrier,cRGD,peptide,tumor,targeting,which,constituted,nano,NPs,fluorescence,imaging,guided,comparable,PEG,without,unit,was,also,prepared,illustration,therapeutic,performance,Attribute,role,accumulate,enter,show,superior,than,vitro,vivo,reveals,that,enrich,tissues,within,good,biocompatibility
AB值：
0.62643
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
