典型文献
Macroencapsulation Devices for Cell Therapy
文献摘要：
Macroencapsulation has been widely used in cell therapy due to its capability to provide immune-privileged sites for implanted allogeneic or xenogeneic cells.Macroencapsulation also serves to provide mechanical and physiochemical support for maintaining cell expansion and promoting therapeutic func-tions.Macroencapsulation devices such as membrane-controlled release systems,hydrogels,micronee-dle(MN)array patches,and three-dimensional(3D)stents have shown promising in-lab and preclinical results in the maintenance of long-term cell survival and the strengthening of treatment effi-cacy.Recent studies focus on expanding the applications of these devices to new cell-based areas such as chimeric antigen receptor(CAR)-T cell delivery,cardiovascular disease therapy,and the exploration of new materials,construction methods,and working principles to augment treatment efficacy and prolong therapy duration.Here,we survey innovative platforms and approaches,as well as translation outcomes,for advancing the performance and applications of macrodevices for cell-based therapies.A discussion and critique regarding future opportunities and challenges is also provided.
文献关键词：
中图分类号：
作者姓名：
Wei Liu;Yanfang Wang;Jinqiang Wang;Olivia L.Lanier;Marissa E.Wechsler;Nicholas A.Peppas;Zhen Gu
作者机构：
Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China;Department of Biomedical Engineering,The University of Texas at Austin,Austin,TX 78712,USA;Department of Biomedical Engineering and Chemical Engineering,The University of Texas at San Antonio,San Antonio,TX 78249,USA;Division of Molecular Pharmaceutics and Drug Delivery,College of Pharmacy,The University of Texas at Austin,Austin,TX 78712,USA;Zhejiang Laboratory of Systems and Precision Medicine,Zhejiang University Medical Center,Hangzhou 311121,China;MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China
文献出处：
引用格式：
[1]Wei Liu;Yanfang Wang;Jinqiang Wang;Olivia L.Lanier;Marissa E.Wechsler;Nicholas A.Peppas;Zhen Gu-.Macroencapsulation Devices for Cell Therapy)[J].工程（英文）,2022(06):53-70
A类：
Macroencapsulation,micronee,macrodevices
B类：
Devices,Cell,Therapy,has,been,widely,used,therapy,due,its,capability,immune,privileged,sites,implanted,allogeneic,xenogeneic,cells,also,serves,mechanical,physiochemical,support,maintaining,expansion,promoting,therapeutic,func,such,membrane,controlled,release,systems,hydrogels,dle,MN,array,patches,three,dimensional,stents,have,shown,promising,lab,preclinical,results,maintenance,term,survival,strengthening,treatment,Recent,studies,focus,expanding,applications,these,new,areas,chimeric,antigen,receptor,CAR,delivery,cardiovascular,disease,exploration,materials,construction,methods,working,principles,augment,efficacy,prolong,duration,Here,survey,innovative,platforms,approaches,well,translation,outcomes,advancing,performance,therapies,discussion,critique,regarding,future,opportunities,challenges,provided
AB值：
0.649532
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