典型文献
Liposome-based anchoring and core-encapsulation for combinatorial cancer therapy
文献摘要：
Downregulated pro-apoptotic protein in cancer cells compromises the chemotherapy by a cytotoxic drug.Here,we report co-delivery of a pro-apoptotic protein,caspase 3(Cas 3),and cytotoxic agent,oridonin(ORD),for synergistic cancer treatment,using a method of liposome-based anchoring and core encapsu-lation.First,ORD is modified with hyaluronic acid(HA)to improve its solubility.Then,the targeted co-delivery system is prepared by assembling the conjugate HA-ORD onto the Cas 3-loaded liposomes,which the surface HA can target the CD44 receptor on cancer cells.In vitro,the co-loaded liposomes(120 nm)are specifically taken up by 4T1 cells and endow a 1.5-fold increase of Cas 3.After intravenous injection into the tumor-bearing mice,the liposomes accumulate in the tumor with high efficacy and significantly inhibit tumor growth via promoting apoptosis and anti-proliferation of cancer cells.Mechanistically,the co-delivery works synergistically by upregulating the activated Cas form,cleaved-Cas 3.
文献关键词：
中图分类号：
作者姓名：
Qingqing Xiao;Xiaotong Li;Chang Liu;Yi Yang;Yuqi Hou;Ying Wang;Mengxiang Su;Wei He
作者机构：
School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China
文献出处：
引用格式：
[1]Qingqing Xiao;Xiaotong Li;Chang Liu;Yi Yang;Yuqi Hou;Ying Wang;Mengxiang Su;Wei He-.Liposome-based anchoring and core-encapsulation for combinatorial cancer therapy)[J].中国化学快报（英文版）,2022(09):4191-4196
A类：
Liposome,Downregulated,oridonin
B类：
anchoring,core,encapsulation,combinatorial,cancer,apoptotic,protein,cells,compromises,chemotherapy,by,cytotoxic,drug,Here,we,report,delivery,caspase,Cas,agent,ORD,treatment,using,method,First,modified,hyaluronic,acid,HA,improve,its,solubility,Then,targeted,system,prepared,assembling,conjugate,onto,loaded,liposomes,which,surface,CD44,receptor,In,vitro,specifically,taken,4T1,endow,fold,increase,After,intravenous,injection,into,tumor,bearing,mice,accumulate,high,efficacy,significantly,inhibit,growth,via,promoting,apoptosis,anti,proliferation,Mechanistically,works,synergistically,upregulating,activated,form,cleaved
AB值：
0.539993
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