典型文献
Exosome based miRNA delivery strategy for disease treatment
文献摘要：
miRNA,which is a common non-coding RNA,can target various mRNAs to regulate their physiological activities.Therefore,miRNAs play an important role in various physiological and pathological processes,and so they have been proposed as a powerful tool to treat different diseases efficiently.However,the characteristic of miRNA degradation in vivo limits its further clinical application.Exosomes have the ad-vantage of crossing the biological barrier and achieving long-distance communication with cells,so they are excellent vectors for miRNAs.By studying the biogenesis of exosomes,the way for loading miRNAs,the mechanism of targeting,and disease occurrence and development,it is confirmed that exosomes can enrich specific endogenous miRNAs and regulate a variety of physiological activities,such as pro-moting cancer cell apoptosis,regulating lipid metabolism and promoting angiogenesis.It is shown that exosomes loaded with miRNAs have good performance in the fields of cancer,neurodegenerative diseases,cardiovascular disease treatment,and regenerative medicine.In this paper,the application and research progress of exosomes carrying miRNA in the above fields are systematically described.
文献关键词：
中图分类号：
作者姓名：
Zhengwen Fang;Xinyu Zhang;Hai Huang;Jun Wu
作者机构：
School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China;Department of Drug Clinical Trial Institution,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hosptial,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China;Department of Urology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510220,China
文献出处：
引用格式：
[1]Zhengwen Fang;Xinyu Zhang;Hai Huang;Jun Wu-.Exosome based miRNA delivery strategy for disease treatment)[J].中国化学快报（英文版）,2022(04):1693-1704
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B类：
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AB值：
0.599956
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