Macrophage is the key innate immune effector in first-line defense against the pathogens,and can be polarized into different phenotypes to regulate a variety of immunological functions.However,the plas-ticity of macrophage is extraordinarily recruited,activated,and polarized under pathological conditions,playing paramount roles in occurrence,development,and prognosis of various chronic diseases,such as rheumatoid arthritis(RA),atherosclerosis(AS),and cancer.To this end,macrophage has become an im-portant therapeutic target for etiological treatment of these diseases.Meanwhile,with the development of nanotechnology,various nano-drug delivery systems have been explored to target macrophages for disease modulation,displaying unique advantages to address both pharmaceutic and biopharmaceutic limitations of various drugs.This review aims to summarize the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy.First,the origin,polarization and biological functions of macrophages have been introduced,in which macrophages can differentiate into different phenotypes in response to physiological stimuli to play various immunological roles.Then,the macrophage disorder has been reviewed in related with various chronic diseases,and several representative diseases,includ-ing AS,RA,obesity,and cancer,have been discussed in detail to elucidate the pathological contributions of macrophages for disease progress.Next,strategies to regulate macrophages for diseases immunother-apy,such as macrophages depletion,macrophage reprograming,inhibition of macrophage recruitment,are summarized,and particular attention has been paid on bio-functional nanomaterials to engineer macrophages via different mechanisms.Further,methods for macrophage-targeting delivery nanosystems are discussed based on both passive and active targeting approaches.Finally,the perspective is specu-lated for potential clinical translation,and there still has significant room for the development of novel macrophage-targeting nanomedicine for precise,effective,and biosafe therapy.

Yuejia Song;Yaqian Huang;Fang Zhou;Jinsong Ding;Wenhu Zhou

Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China;Department of Pharmacy,Southern University of Science and Technology Hospital,Shenzhen 518055,China;Academician Workstation,Changsha Medical University,Changsha 410219,China

中国化学快报（英文版）

[1]Yuejia Song;Yaqian Huang;Fang Zhou;Jinsong Ding;Wenhu Zhou-.Macrophage-targeted nanomedicine for chronic diseases immunotherapy)[J].中国化学快报（英文版）,2022(02):597-612

pharmaceutic,biopharmaceutic,immunother,specu,biosafe

Macrophage,targeted,nanomedicine,chronic,diseases,immunotherapy,key,innate,immune,effector,first,line,defense,against,pathogens,polarized,into,phenotypes,regulate,variety,immunological,functions,However,plas,ticity,extraordinarily,recruited,activated,under,pathological,conditions,paramount,roles,occurrence,development,prognosis,various,such,rheumatoid,arthritis,RA,atherosclerosis,AS,cancer,To,this,end,has,become,portant,therapeutic,etiological,treatment,these,Meanwhile,nanotechnology,delivery,have,been,explored,macrophages,modulation,displaying,unique,advantages,address,both,limitations,drugs,This,aims,recent,progress,First,origin,polarization,biological,introduced,which,differentiate,response,physiological,stimuli,Then,disorder,reviewed,related,several,representative,includ,obesity,discussed,detail,elucidate,contributions,Next,strategies,depletion,reprograming,inhibition,recruitment,are,summarized,particular,attention,paid,functional,nanomaterials,engineer,via,mechanisms,Further,methods,targeting,nanosystems,passive,active,approaches,Finally,perspective,potential,clinical,translation,there,still,significant,room,novel,precise,effective

0.515369