典型文献
Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis
文献摘要：
Protein-based drugs have received extensive attention in the field of drug research in recent years.How-ever,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This study developed bifunctional oral lipid polymer hybrid nanoparticles(R8-PEG-PPNPs)that deliver superoxide dismutase(SOD)for the treatment of ulcerative colitis(UC).R8-PEG-PPNPs was composed of PCADK,PLGA,lecithin,and co-modified with stearic acid-octa-arginine and polyethylene glycol.The nanoparticles(NPs)are uniformly dispersed with a complete spherical structure.In vitro stability and release studies showed that R8-PEG-PPNPs exhibited good stability and protection.In vitro cell culture experiments demonstrated that R8-PEG-PPNPs as carriers have no significant toxic effects on cells at con-centration below 1000 pg/mL and promote cellular uptake.In experiments with ulcerative colitis mice,R8-PEG-PPNPs were able to enhance drug absorption by intestinal epithelial cells and accumulate effec-tively at the site of inflammation.Its therapeutic effect further demonstrates that R8-PEG-PPNPs are a promising delivery system for oral delivery of protein-based drugs.
文献关键词：
中图分类号：
作者姓名：
Yaxin Cui;Tianyu Zhu;Xueyan Zhang;Jicong Chen;Fengying Sun;Youxin Li;Lesheng Teng
作者机构：
School of Life Sciences,Jilin University,Changchun 130012,China
文献出处：
引用格式：
[1]Yaxin Cui;Tianyu Zhu;Xueyan Zhang;Jicong Chen;Fengying Sun;Youxin Li;Lesheng Teng-.Oral delivery of superoxide dismutase by lipid polymer hybrid nanoparticles for the treatment of ulcerative colitis)[J].中国化学快报（英文版）,2022(10):4617-4622
A类：
PPNPs,PCADK,octa
B类：
Oral,delivery,superoxide,dismutase,by,lipid,polymer,hybrid,nanoparticles,treatment,ulcerative,colitis,Protein,drugs,have,received,extensive,attention,field,research,recent,years,How,ever,protein,activity,difficult,maintain,during,oral,which,limits,application,This,study,developed,bifunctional,R8,PEG,that,UC,was,composed,PLGA,lecithin,modified,stearic,acid,arginine,polyethylene,glycol,are,uniformly,dispersed,complete,spherical,structure,In,vitro,stability,release,studies,showed,exhibited,good,protection,culture,experiments,demonstrated,carriers,significant,toxic,effects,cells,con,centration,below,pg,promote,cellular,uptake,mice,were,able,enhance,absorption,intestinal,epithelial,accumulate,tively,site,inflammation,Its,therapeutic,further,demonstrates,promising,system
AB值：
0.530285
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