Atherosclerosis(AS),mainly caused by the changed immune system functions and inflammation,is the central pathogenesis of cardiovascular disease,which is a leading cause of death in the world.In modern medicine,the development of carriers precisely delivering the therapeutic agents to the target sites is the primary goal,which could minimize the potential adverse effects and be more effective in treating lesions.Due to the precise location,real-time monitoring,AS microenvironment response,and low toxic-ity,stimuli-responsive nano-based drug delivery systems(NDDSs)have been a promising approach in AS treatments.Herein,we will systematically summarize the recent advances in stimuli-responsive NDDSs for AS treatment,including internal stimuli(reactive oxygen species,enzyme,shear stress,and pH)and external stimuli(light,ultrasound,and magnetism)responsive NDDSs.Besides,we will also summarize in detail the classification of stimuli-responsive NDDSs for AS,such as organic NDDSs(e.g.,lipid-based and polymer-based nanomaterials),inorganic NDDSs(e.g.,metal-based nanoparticles and nonmetallic nano-materials),and composite multifunctional NDDSs.Finally,the critical challenges and prospects of this field will also be proposed and discussed.

Yilin Song;Huaqing Jing;Long Binh Vong;Jinping Wang;Nan Li

Tianjin Key Laboratory of Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China;School of Biomedical Engineering,International University,Ho Chi Minh 700000,Vietnam;Vietnam National University Ho Chi Minh City(VNU-HCMC),Ho Chi Minh 700000,Vietnam;Key Laboratory of Molecular Biophysics of Hebei Province,Institute of Biophysics,School of Sciences,Hebei University of Technology,Tianjin 300401,China

中国化学快报（英文版）

[1]Yilin Song;Huaqing Jing;Long Binh Vong;Jinping Wang;Nan Li-.Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis)[J].中国化学快报（英文版）,2022(04):1705-1717

NDDSs

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