典型文献
Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells
文献摘要：
Dear Editor,
Influenza B viruses(IBVs)have circulated among humans for more than 80 years.Seasonal influenza virus epidemics caused by two IBV lines(Victoria and Yamagata)and influenza A virus have considerable effects on public health globally and result in approximately 290,000-650,000 annual influenza-attributed deaths(Caini et al.,2015;Pan et al.,2015).Currently,the most effective countermeasures against influenza B virus infections are influenza virus vaccines(Subbarao and Matsuoka,2013).However,these vaccines have limited efficacy because only strain-matched humoral immune responses are induced,while the globular head domain of viral hemagglutinin(HA)continues to evolve rapidly.In addition,few anti-influenza drugs are available,and the treatment window for administering the available drugs is small(Subbarao and Matsuoka,2013;van de Sandt et al.,2015).A universal drug that targets both influenza B virus lineages remains a public health priority.Conferring passive immune protection using broadly neutral-izing antibodies(bnAbs)may be a promising alternative viral infection treatment(Wilson and Andrews,2012;Corti and Lanzavecchia,2013;Walker and Burton,2018).
文献关键词：
中图分类号：
作者姓名：
Yuanzhi Chen;Chenguang Shen;Jing Chen;Junyu Chen;Fentian Chen;Limin Zhang;Xue Liu;Siyuan Chen;Sen Xue;Yongliang Liu;Jixian Tang;Quan Yuan;Yixin Chen;Wenxin Luo;Ningshao Xia
作者机构：
National Institute of Diagnostics and Vaccine Development in Infectious Diseases,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,School of Public Health&School of Life Science,Xiamen University,Xiamen 361102,China;Biosafety Level-3 Laboratory,School of Public Health,Southern Medical University,Guangzhou 510515,China
文献出处：
引用格式：
[1]Yuanzhi Chen;Chenguang Shen;Jing Chen;Junyu Chen;Fentian Chen;Limin Zhang;Xue Liu;Siyuan Chen;Sen Xue;Yongliang Liu;Jixian Tang;Quan Yuan;Yixin Chen;Wenxin Luo;Ningshao Xia-.Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells)[J].中国病毒学,2022(04):619-622
A类：
hybridoma,
Influenza,IBVs,Caini,Subbarao,Matsuoka,Sandt,bnAbs,Lanzavecchia
B类：
Development,functional,antibodies,against,influenza,by,activation,induced,cytidine,deaminase,cells,Dear,Editor,viruses,have,circulated,among,humans,more,than,years,Seasonal,epidemics,caused,two,lines,Victoria,Yamagata,considerable,effects,public,health,globally,result,approximately,annual,attributed,deaths,Pan,Currently,most,effective,countermeasures,infections,are,vaccines,However,these,limited,efficacy,because,only,strain,matched,humoral,immune,responses,while,globular,head,domain,viral,hemagglutinin,HA,continues,evolve,rapidly,addition,few,drugs,available,treatment,window,administering,small,van,universal,that,targets,both,lineages,remains,priority,Conferring,passive,protection,using,broadly,neutral,izing,may,promising,alternative,Wilson,Andrews,Corti,Walker,Burton
AB值：
0.598511
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