The outbreak and spread of coronavirus disease 2019(COVID-19)highlighted the impor-tance and urgency of the research and development of therapeutic drugs.Very early into the COVID-19 pandemic,China has begun developing drugs,with some notable progress.Herein,we summarizes the anti-COVID-19 drugs and promising drug candidates originally developed and researched in China.Furthermore,we discussed the developmental prospects,mechanisms of action,and advantages and dis-advantages of the anti-COVID-19 drugs in development,with the aim to contribute to the rational use of drugs in COVID-19 treatment and more effective development of new drugs against severe acute respi-ratory syndrome coronavirus 2(SARS-CoV-2)and the variants.Neutralizing antibody is an effective approach to overcome COVID-19.However,drug resistance induced by rapid virus mutation will likely to challenge neutralizing antibodies.Taking into account current epidemic trends,small molecule drugs have a crucial role in fighting COVID-19 due to their significant advantage of convenient administration and affordable and broad-spectrum.Traditional Chinese medicines,including natural products and tradi-tional Chinese medicine prescriptions,contribute to the treatment of COVID-19 due to their unique mechanism of action.Currently,the research and development of Chinese anti-COVID-19 drugs have led to some promising achievements,thus prompting us to expect even more rapidly available solutions.

Xiwei Ji;Xiangrui Meng;Xiao Zhu;Qingfeng He;Yimin Cui

Institute of Clinical Pharmacology,Peking University First Hospital,Beijing 100034,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Department of Clinical Pharmacy and Pharmacy Administration,School of Pharmacy,Fudan University,Shanghai 201203,China

药学学报（英文版）

[1]Xiwei Ji;Xiangrui Meng;Xiao Zhu;Qingfeng He;Yimin Cui-.Research and development of Chinese anti-COVID-19 drugs)[J].药学学报（英文版）,2022(12):4271-4286

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