The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID-19 complications and poor outcomes. Abundant data have shown that many COVID-19 vaccines are safe and effective in large-scale populations; however, these clinical trials have excluded immunocompromised populations. Available evidence indicates that immunocompromised populations have a blunted immune response to other vaccines, raising concerns regarding the efficacy of COVID-19 vaccination in these populations. Thus, there is an urgent need to delineate the efficacy of COVID-19 vaccines in these vulnerable populations. Here, we review the characteristics of specific humoral and cellular responses to COVID-19 vaccination in immunocompromised populations, including HIV-infected patients and those receiving immunosuppressive treatment, especially solid organ transplant recipients and those undergoing anti-CD20 treatment. We also addressed the challenges that immunocompromised populations will face in the future pandemic and the need for basic and clinical translational studies to highlight the best vaccination strategies for these populations.

Anti-CD20 treatment;Coronavirus disease 2019;Human immunodeficiency virus;Immunocompromised;Solid organ transplant recipient;Vaccine

Song Jin-Wen;Hu Wei;Shen Lili;Wang Fu-Sheng

Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China;Department of Emergency, The Fifth Medical Center of Chinese PLA Hospital, Beijing 100039, China;Department of Clinical Medicine, Bengbu Medical College, Bengbu, Anhui 233030, China

中华医学杂志（英文版）

[1]Song Jin-Wen;Hu Wei;Shen Lili;Wang Fu-Sheng-.Safety and immunogenicity of COVID-19 vaccination in immunocompromised patients)[J].中华医学杂志（英文版）,2022(22):2656-2666

Immunocompromised

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