典型文献
Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo
文献摘要：
Dear Editor,
The outbreak of coronavirus disease 2019(COVID-19)has resulted in a severe global pandemic that has lasted for more than two years.1 Several vaccines were developed at an unprecedented speed to protect billions of people.2 Many monoclonal antibodies have also been discovered,several of which are in the clinical stages.3 However,limited vaccine availability and vaccine hesi-tancy compromise the impact of vaccines.The continuous evolution of SARS-CoV-2 has also resulted in many variants that can escape immunity,reducing the effects of vaccines and antibodies.4 With more than 30 mutations in the spike protein,the Omicron variant escapes the majority of existing antibodies and extensively evades vaccine-induced immunity.56 Thus,therapeu-tics that are broadly effective against current and future emerging SARS-CoV-2 variants are still highly desirable.
文献关键词：
中图分类号：
作者姓名：
Mengjiao Li;Zi-Wei Ye;Kaiming Tang;Liang Guo;Wenwen Bi;Yuyuan Zhang;Yan-dong Tang;Guoguang Rong;Mohamad Sawan;Xin Yin;Ren Sun;Shuofeng Yuan;Bobo Dang
作者机构：
Fudan University,Shanghai,China;Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,Hangzhou,Zhejiang,China;Center for Infectious Disease Research,Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou,Zhejiang,China;Institute of Biology,Westlake Institute for Advanced Study,Hangzhou,Zhejiang,China;Department of Microbiology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China;State Key Laboratory of Emerging Infectious Diseases,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China;State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin,China;CenBRAIN Lab.,School of Engineering,Westlake University,Hangzhou,Zhejiang,China;CenBRAIN Lab.,Westlake Institute for Advanced Study,Hangzhou,Zhejiang,China;School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China
文献出处：
引用格式：
[1]Mengjiao Li;Zi-Wei Ye;Kaiming Tang;Liang Guo;Wenwen Bi;Yuyuan Zhang;Yan-dong Tang;Guoguang Rong;Mohamad Sawan;Xin Yin;Ren Sun;Shuofeng Yuan;Bobo Dang-.Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo)[J].细胞研究（英文版）,2022(06):589-592
A类：
hesi,tancy,evades
B类：
Enhanced,trimeric,ACE2,exhibits,potent,prophylactic,therapeutic,efficacy,against,SARS,CoV,Delta,Omicron,variants,vivo,Dear,Editor,
The,outbreak,coronavirus,disease,has,resulted,severe,global,pandemic,that,lasted,more,than,two,years,Several,vaccines,were,developed,unprecedented,speed,protect,billions,people,Many,monoclonal,antibodies,have,also,been,discovered,several,which,are,clinical,stages,However,limited,availability,compromise,impact,continuous,evolution,many,can,immunity,reducing,effects,With,mutations,spike,protein,escapes,majority,existing,extensively,induced,Thus,tics,broadly,effective,current,future,emerging,still,highly,desirable
AB值：
0.633729
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
