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典型文献
Cell membrane coated-nanoparticles for cancer immunotherapy
文献摘要:
Cancer immunotherapy can effectively inhibit cancer progression by activating the autoim-mune system,with low toxicity and high effectiveness.Some of cancer immunotherapy had positive ef-fects on clinical cancer treatment.However,cancer immunotherapy is still restricted by cancer heterogeneity,immune cell disability,tumor immunosuppressive microenvironment and systemic im-mune toxicity.Cell membrane-coated nanoparticles(CMCNs)inherit abundant source cell-relevant func-tions,including"self'markers,cross-talking with the immune system,biological targeting,and homing to specific regions.These enable them to possess preferred characteristics,including better biological compatibility,weak immunogenicity,immune escaping,a prolonged circulation,and tumor targeting.Therefore,they are applied to precisely deliver drugs and promote the effect of cancer immunotherapy.In the review,we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy,outline the existing specific cancer immune therapies,explore the unique functions and molecular mech-anisms of various cell membrane-coated nanoparticles,and analyze the challenges which CMCNs face in clinical translation.
文献关键词:
作者姓名:
Yingping Zeng;Sufen Li;Shufen Zhang;Li Wang;Hong Yuan;Fuqiang Hu
作者机构:
College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China
引用格式:
[1]Yingping Zeng;Sufen Li;Shufen Zhang;Li Wang;Hong Yuan;Fuqiang Hu-.Cell membrane coated-nanoparticles for cancer immunotherapy)[J].药学学报(英文版),2022(08):3233-3254
A类:
CMCNs
B类:
Cell,membrane,coated,nanoparticles,cancer,immunotherapy,Cancer,effectively,inhibit,progression,by,activating,autoim,low,toxicity,high,effectiveness,Some,had,positive,fects,clinical,treatment,However,still,restricted,heterogeneity,immune,cell,disability,tumor,immunosuppressive,microenvironment,systemic,inherit,abundant,source,relevant,including,self,markers,cross,talking,biological,targeting,homing,specific,regions,These,enable,them,possess,preferred,characteristics,better,compatibility,weak,immunogenicity,escaping,prolonged,circulation,Therefore,they,are,applied,precisely,deliver,drugs,promote,In,review,summarize,latest,researches,biomimetic,outline,existing,therapies,explore,unique,functions,molecular,mech,anisms,various,analyze,challenges,which,face,translation
AB值:
0.601779
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