典型文献
Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death
文献摘要：
Tumor immunotherapy,especially immune checkpoint blockade(ICB),has revolutionized the cancer field.However,the limited response of tumors to immunotherapy is a major obstacle.Tumor immunogenic cell death(ICD)is a death mode of tumor cells that can promote tumor immunity.ICD can induce strong an-titumor immune responses through the ectopic exposure of calreticulin on the plasma membrane surface and the release of the non-histone nuclear protein high-mobility group box 1(HMGB1),ATP,and in-terferon(IFN),thus activating an adaptive immune response against dead cell-associated antigens and enhancing the therapeutic effect of tumor immunotherapy.Chemotherapy,radiotherapy,photothermal therapy,magneto-thermodynamics therapy,nanopulse stimulation,and oncolytic virus therapy can all induce a strong antitumor immune response by ICD.In addition,the application of nanotechnology can precisely target drug delivery and improve the efficacy of immunotherapy.Here we introduce the basic concepts and molecular mechanisms underlying the induction of ICD.Then,we summarize and discuss the progress in the application of nanotechnology in immunotherapy to promote ICD.Finally,we attempt to define the challenges and future directions in this area to extend the benefits of ICD to a broader patient population.
文献关键词：
中图分类号：
作者姓名：
Lvqin Fu;Xianbin Ma;Yuantong Liu;Zhigang Xu;Zhijun Sun
作者机构：
The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China;Key Laboratory of Luminescence Analysis and Molecular Sensing,Ministry of Education,School of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices,Southwest University,Chongqing 400715,China
文献出处：
引用格式：
[1]Lvqin Fu;Xianbin Ma;Yuantong Liu;Zhigang Xu;Zhijun Sun-.Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death)[J].中国化学快报（英文版）,2022(04):1718-1728
A类：
titumor,terferon,nanopulse
B类：
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AB值：
0.596058
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