典型文献
Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications
文献摘要：
Immunotherapy that targets checkpoints, especially programmed cell death protein 1 and programmed cell death ligand 1, has revolutionized cancer therapy regimens. The overall response rate to mono-immunotherapy, however, is limited, emphasizing the need to potentiate the efficacy of these regimens. The functions of immune cells are modulated by multiple stimulatory and inhibitory molecules, including lymphocyte activation gene 3 (LAG-3). LAG-3 is co-expressed together with other inhibitory checkpoints and plays key roles in immune suppression. Increasing evidence, particularly in the last 5 years, has shown the potential of LAG-3 blockade in anti-tumor immunity. This review provides an update on the biological properties and clinical applications of LAG-3 in cancers.
文献关键词：
Lymphocyte-activation gene 3 (LAG-3);Immune checkpoint;Cancer;Immunotherapy
中图分类号：
作者姓名：
Zhao Lishu;Wang Hao;Xu Kandi;Liu Xinyue;He Yayi
作者机构：
Department of Medical Oncology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China;School of Medicine, Tongji University, Shanghai 200092, China
文献出处：
引用格式：
[1]Zhao Lishu;Wang Hao;Xu Kandi;Liu Xinyue;He Yayi-.Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications)[J].中华医学杂志（英文版）,2022(10):1203-1212
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B类：
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AB值：
0.609268
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