典型文献
Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy
文献摘要：
Immunotherapy,in particular immune checkpoint blockade(ICB)therapy targeting the programmed cell death-1(PD-1)/programmed cell death ligand-1(PD-L1)axis,has remarkably revolutionized cancer treatment in the clinic.Anti-PD-1/PD-L1 therapy is designed to restore the antitumor response of cytotoxic T cells(CTLs)by blocking the interaction between PD-L1 on tumour cells and PD-1 on CTLs.Nevertheless,current anti-PD-1/PD-L1 therapy suffers from poor therapeutic outcomes in a large variety of solid tumours due to insufficient tumour specificity,severe cytotoxic effects,and the occurrence of immune resistance.In recent years,nanosized drug delivery systems(NDDSs),endowed with highly efficient tumour targeting and versatility for combination therapy,have paved a new avenue for cancer immunotherapy.In this review article,we summarized the recent advances in NDDSs for anti-PD-1/PD-L1 therapy.We then discussed the challenges and further provided perspectives to promote the clinical application of NDDS-based anti-PD-1/PD-L1 therapy.
文献关键词：
中图分类号：
作者姓名：
Jun-hao Li;Lu-jia Huang;Hui-ling Zhou;Yi-ming Shan;Fang-min Chen;Vesa-Pekka Lehto;Wu-jun Xu;Li-qiang Luo;Hai-jun Yu
作者机构：
College of Sciences,Shanghai University,Shanghai 200444,China;State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;University of Chinese Academy of Sciences,Beijing 100049,China;Department of Applied Physics,University of Eastern Finland,70211 Kuopio,Finland
文献出处：
引用格式：
[1]Jun-hao Li;Lu-jia Huang;Hui-ling Zhou;Yi-ming Shan;Fang-min Chen;Vesa-Pekka Lehto;Wu-jun Xu;Li-qiang Luo;Hai-jun Yu-.Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy)[J].中国药理学报（英文版）,2022(11):2749-2758
A类：
NDDSs
B类：
Engineered,nanomedicines,L1,axis,potentiated,cancer,immunotherapy,Immunotherapy,particular,immune,checkpoint,blockade,ICB,targeting,programmed,death,ligand,has,remarkably,revolutionized,treatment,Anti,designed,restore,antitumor,response,cytotoxic,cells,CTLs,by,blocking,interaction,between,Nevertheless,current,suffers,from,poor,therapeutic,outcomes,large,variety,solid,tumours,due,insufficient,specificity,severe,effects,occurrence,resistance,In,recent,years,nanosized,drug,delivery,systems,endowed,highly,efficient,versatility,combination,have,paved,new,avenue,this,review,article,summarized,advances,We,then,discussed,challenges,further,provided,perspectives,promote,clinical,application
AB值：
0.583143
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