典型文献
Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy
文献摘要：
Immunotherapy that activates immune systems for combating cancer has yielded considerable clinical benefits recently.However,the immunosuppressive tumor microenvironment(ITME)is a major hurdle to immunotherapy as it supports tumor to evade immune surveillance.Reversing ITME facilitates the recruitment and activation of antitumor immune cells,thereby promoting immunotherapy.Our group has developed various nanosized drug delivery systems(NDDSs)to modulate ITME with enhanced efficacy and safety.In the review we introduce the ITME-remodeling strategies for improving immunotherapy based on NDDSs including triggering tumor cells to undergo immunogenetic cell death(ICD),applying tumor vaccine,and directly regulating intratumoral immune components(immune cells or cytokines).In order to guide the design of NDDSs for amplified effects of antitumor immunotherapy,the contributions and future directions of this field are also discussed.
文献关键词：
中图分类号：
作者姓名：
Wen-lu Yan;Tian-qun Lang;Wen-hui Yuan;Qi Yin;Ya-ping Li
作者机构：
State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,501 Haike Road,Shanghai 201203,China;School of Pharmacy,University of Chinese Academy of Sciences,Beijing 100049,China;Yantai Key Laboratory of Nanomedicine&Advanced Preparations,Yantai Institute of Materia Medica,Yantai 264000,China;Shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai 264117,China;School of Pharmacy,Yantai University,Yantai 264005,China
文献出处：
引用格式：
[1]Wen-lu Yan;Tian-qun Lang;Wen-hui Yuan;Qi Yin;Ya-ping Li-.Nanosized drug delivery systems modulate the immunosuppressive microenvironment to improve cancer immunotherapy)[J].中国药理学报（英文版）,2022(12):3045-3054
A类：
ITME,NDDSs,immunogenetic
B类：
Nanosized,drug,delivery,systems,modulate,immunosuppressive,microenvironment,improve,cancer,immunotherapy,Immunotherapy,that,activates,immune,combating,has,yielded,considerable,clinical,benefits,recently,However,major,hurdle,supports,evade,surveillance,Reversing,facilitates,recruitment,activation,antitumor,cells,thereby,promoting,Our,group,developed,various,nanosized,enhanced,efficacy,safety,In,review,introduce,remodeling,strategies,improving,including,triggering,undergo,death,ICD,applying,vaccine,directly,regulating,intratumoral,components,cytokines,order,guide,design,amplified,effects,contributions,future,directions,this,field,are,also,discussed
AB值：
0.57562
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