典型文献
Bacterial outer membrane vesicle-based cancer nanovaccines
文献摘要：
Tumor vaccines, a type of personalized tumor immunotherapy, have developed rapidly in recent decades. These vaccines evoke tumor antigen-specific T cells to achieve immune recognition and killing of tumor cells. Because the immunogenicity of tumor antigens alone is insufficient, immune adjuvants and nanocarriers are often required to enhance anti-tumor immune responses. At present, vaccine carrier development often integrates nanocarriers and immune adjuvants. Among them, outer membrane vesicles (OMVs) are receiving increasing attention as a delivery platform for tumor vaccines. OMVs are natural nanovesicles derived from Gram-negative bacteria, which have adjuvant function because they contain pathogen associated molecular patterns. Importantly, OMVs can be functionally modified by genetic engineering of bacteria, thus laying a foundation for applications as a delivery platform for tumor nanovaccines. This review summarizes 5 aspects of recent progress in, and future development of, OMV-based tumor nanovaccines: strain selection, heterogeneity, tumor antigen loading, immunogenicity and safety, and mass production of OMVs.
文献关键词：
中图分类号：
作者姓名：
Xiaoyu Gao;Qingqing Feng;Jing Wang;Xiao Zhao
作者机构：
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China;Center of Drug Evaluation,National Medical Products Administration,Beijing 100022,China;IGDB-NCNST Joint Research Center,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China
文献出处：
引用格式：
[1]Xiaoyu Gao;Qingqing Feng;Jing Wang;Xiao Zhao-.Bacterial outer membrane vesicle-based cancer nanovaccines)[J].癌症生物学与医学（英文版）,2022(09):1290-1300
A类：
nanovaccines
B类：
Bacterial,outer,membrane,cancer,Tumor,type,personalized,tumor,immunotherapy,have,developed,rapidly,recent,decades,These,evoke,specific,cells,achieve,immune,recognition,killing,Because,immunogenicity,antigens,alone,insufficient,adjuvants,nanocarriers,are,often,required,enhance,responses,At,present,development,integrates,Among,them,OMVs,receiving,increasing,attention,delivery,platform,natural,nanovesicles,derived,from,Gram,negative,bacteria,which,because,they,contain,pathogen,associated,molecular,patterns,Importantly,functionally,modified,by,genetic,engineering,thus,laying,foundation,applications,This,review,summarizes,aspects,progress,future,strain,selection,heterogeneity,loading,safety,mass,production
AB值：
0.568191
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