典型文献
Treatments for resectable esophageal cancer: from traditional systemic therapy to immunotherapy
文献摘要：
Esophageal cancer (EC) has a high incidence and poor prognosis. The two major histological types, squamous cell carcinoma and adenocarcinoma, differ in their epidemiology and treatment options. Patients with locally advanced EC benefit from multimodal therapy concepts including neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, and perioperative chemotherapy. Currently, immunotherapy for the solid tumor is a hot spot. Treatment with adjuvant immune checkpoint inhibitors (ICIs) is the first immunotherapy for resectable EC listed in the latest National Comprehensive Cancer Network Guidelines for the Esophageal and Esophagogastric Junction Cancers. Recent clinical trials have established ICIs for three treatment models of resectable EC. Their short-term results demonstrated ideal efficacy and tolerable toxicity, though some concerns remain. This review summarizes the novel data on the ICIs for resectable EC and lists the registered related clinical trials. Hopefully, this review can provide a reference for ongoing research on the treatment options for resectable EC.
文献关键词：
Esophageal cancer;Immune checkpoint inhibitor;Immunotherapy
中图分类号：
作者姓名：
Yan Yan;Feng Xijia;Li Chengqiang;Lerut Toni;Li Hecheng
作者机构：
Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Department of Thoracic Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Department of Thoracic Surgery, University Hospital Gasthuisberg, University of Leuven, Leuven 3000, Belgium
文献出处：
引用格式：
[1]Yan Yan;Feng Xijia;Li Chengqiang;Lerut Toni;Li Hecheng-.Treatments for resectable esophageal cancer: from traditional systemic therapy to immunotherapy)[J].中华医学杂志（英文版）,2022(18):2143-2156
A类：
Esophagogastric
B类：
Treatments,resectable,esophageal,cancer,from,traditional,systemic,immunotherapy,Esophageal,EC,has,high,incidence,poor,prognosis,major,histological,types,squamous,cell,adenocarcinoma,differ,their,epidemiology,treatment,options,Patients,locally,advanced,benefit,multimodal,concepts,including,neoadjuvant,chemotherapy,chemoradiotherapy,perioperative,Currently,solid,tumor,hot,spot,immune,checkpoint,inhibitors,ICIs,first,listed,latest,National,Comprehensive,Network,Guidelines,Junction,Cancers,Recent,clinical,trials,have,established,three,models,Their,short,term,results,demonstrated,ideal,efficacy,tolerable,toxicity,though,some,concerns,remain,This,review,summarizes,novel,data,lists,registered,related,Hopefully,this,provide,reference,ongoing,research,Immune,Immunotherapy
AB值：
0.628423
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
