典型文献
Neoantigens in precision cancer immunotherapy: from identification to clinical applications
文献摘要：
Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass spectrometry; and bioinformatics tools based on high-throughput sequencing data, mass spectrometry data, and biological databases. Neoantigen-related therapies are widely used in clinical practice and include neoantigen vaccines, neoantigen-specific CD8+ and CD4+ T cells, and neoantigen-pulsed dendritic cells. In addition, neoantigens can be used as biomarkers to assess immunotherapy response, resistance, and prognosis. Therapies based on neoantigens are an important and promising branch of cancer immunotherapy. Unremitting efforts are needed to unravel the comprehensive role of neoantigens in anti-tumor immunity and to extend their clinical application. This review aimed to summarize the progress in neoantigen research and to discuss its opportunities and challenges in precision cancer immunotherapy.
文献关键词：
Precision cancer immunotherapy;Neoantigen;Anti-tumor immunity;T cells;Vaccination
中图分类号：
作者姓名：
Zhang Qiao;Jia Qingzhu;Zhang Jing;Zhu Bo
作者机构：
Institute of Cancer, Xinqiao Hospital, Army Medical University, Chongqing 400037, China;Department of Hematology and Oncology, The 988th Hospital of Joint Logistic Support Force of PLA, Kaifeng, Henan 475003, China;Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
文献出处：
引用格式：
[1]Zhang Qiao;Jia Qingzhu;Zhang Jing;Zhu Bo-.Neoantigens in precision cancer immunotherapy: from identification to clinical applications)[J].中华医学杂志（英文版）,2022(11):1285-1298
A类：
Neoantigens,Immunotherapies,Neoantigen,Therapies,Unremitting
B类：
precision,cancer,immunotherapy,from,identification,clinical,applications,targeting,neoantigens,are,safe,effective,precise,be,identified,mainly,by,genomic,techniques,such,next,generation,sequencing,high,throughput,single,proteomic,mass,spectrometry,bioinformatics,tools,biological,databases,related,widely,used,practice,include,vaccines,specific,CD8+,CD4+,cells,pulsed,dendritic,In,addition,biomarkers,assess,response,resistance,prognosis,important,promising,branch,efforts,needed,unravel,comprehensive,role,tumor,immunity,extend,their,This,review,aimed,summarize,progress,research,discuss,its,opportunities,challenges,Precision,Anti,Vaccination
AB值：
0.490613
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