典型文献
A DNA Nano-train Carrying a Predefined Drug Combination for Cancer Therapy
文献摘要：
Herein,we reported a tumor cell-targeting aptamer-nano-train to deliver paclitaxel(PTX)and combretastatin A4(CA4)at a predefined ratio to cancer cells based on DNA nanotechnology.Such a drug-carrying aptamer-nano-train(aptamer-NT-PTX/CA4)was prepared via self-assembly of two DNA hairpins,which were conjugated with PTX and CA4,respectively,induced by aptamer trigger.Our research revealed that the aptamer-NT-PTX/CA4 could specifically recognize CD71-positive cancer cells,but not CD71-negative healthy normal cells,and achieve synergistic therapeutic effect on cancer cells.The aptamer-nano-train-based strategy is simple and efficient,and provides a new platform for drug combination cancer therapy.
文献关键词：
中图分类号：
作者姓名：
HUANG Qin;LIU Xin;ZHANG Pengge;WU Zhan;ZHAO Zilong
作者机构：
Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research of Ministry of Education,College of Chemistry and Chemical Engineering,Hunan Normal University,Changsha 410081,P.R.China;Molecular Science and Biomedicine Laboratory(MBL),State Key Labora-tory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410012,P.R.China
文献出处：
引用格式：
[1]HUANG Qin;LIU Xin;ZHANG Pengge;WU Zhan;ZHAO Zilong-.A DNA Nano-train Carrying a Predefined Drug Combination for Cancer Therapy)[J].高等学校化学研究（英文版）,2022(04):928-934
A类：
Predefined,hairpins
B类：
Nano,train,Carrying,Drug,Combination,Cancer,Therapy,Herein,reported,tumor,targeting,aptamer,deliver,paclitaxel,PTX,combretastatin,CA4,predefined,ratio,cancer,cells,nanotechnology,Such,drug,carrying,NT,was,prepared,via,self,assembly,two,which,were,conjugated,respectively,induced,by,trigger,Our,research,revealed,that,could,specifically,recognize,CD71,positive,but,negative,healthy,normal,achieve,synergistic,therapeutic,effect,strategy,simple,efficient,provides,new,platform,combination,therapy
AB值：
0.569664
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