典型文献
Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers
文献摘要：
Affibody molecules are small non-immunoglobulin affinity proteins,which can pre-cisely target to some cancer cells with specific overexpressed molecular signatures.However,the relatively short in vivo half-life of them seri-ously limited their application in drug targeted delivery for cancer therapy.Here an amphiphilic affibody-drug conjugate is self-assembled into nanomicelles to prolong circulation time for targeted cancer therapy.As an example of the concept,the nanoagent was prepared through molecular self-assembly of the amphiphilic con-jugate of ZHER2:342-Cys with auristatin E derivate,where the affibody used is capable of binding to the human epidermal growth factor receptor 2(HER2).Such a nanodrug not only increased the blood circulation time,but also enhanced the tumor targeting capacity (abundant affibody arms on the nanoagent surface) and the drug accumulation in tumor.As a result,this affibody-based nanoagent showed excellent antitumor activity in vivo to HER2-positive ovary and breast tumor models,which nearly eradicated both small solid tumors (about 100 mm3) and large established tumors (exceed 500 mm3).The relative tumor proliferation inhibition ratio reaches 99.8％ for both models.
文献关键词：
中图分类号：
作者姓名：
Xuelin Xia;Xiaoyuan Yang;Wei Huang;Xiaoxia Xia;Deyue Yan
作者机构：
School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules,Shanghai Jiao Tong University,Shanghai 200240,People's Republic of China;State Key Laboratory of Microbial Metabolism,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,People's Republic of China
文献出处：
引用格式：
[1]Xuelin Xia;Xiaoyuan Yang;Wei Huang;Xiaoxia Xia;Deyue Yan-.Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers)[J].纳微快报（英文）,2022(02):190-205
A类：
Nanomicelles,affibody,nanoagent,jugate,ZHER2,auristatin,derivate
B类：
Self,Assembled,Affibody,Drug,Conjugate,Excellent,Therapeutic,Property,Cure,Ovary,Breast,Cancers,molecules,small,immunoglobulin,affinity,proteins,which,cisely,some,cancer,cells,specific,overexpressed,molecular,signatures,However,relatively,short,vivo,half,them,seri,ously,limited,their,application,targeted,delivery,therapy,Here,amphiphilic,conjugate,self,assembled,into,nanomicelles,prolong,circulation,example,concept,was,prepared,through,assembly,Cys,where,used,capable,binding,human,epidermal,growth,receptor,Such,nanodrug,not,only,increased,blood,but,also,enhanced,targeting,capacity,abundant,arms,surface,accumulation,result,this,showed,excellent,antitumor,activity,positive,ovary,breast,models,nearly,eradicated,both,solid,tumors,about,mm3,large,established,exceed,proliferation,inhibition,reaches
AB值：
0.577868
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