Red blood cells(RBCs)have recently emerged as promosing candidates for cancer treatment in terms of relieving tumor hypoxia and inducing oxidative damage against cancer cells,but they are still far from satisfactory due to their limited oxygen transport and reactive oxygen spe-cies generation rate in tumor tissue.Herein,artificial RBCs(designated FTP@RBCM)with radical storm production ability were developed for oncotherapy through multidimensional reactivity pathways of Fe-proto-porphyrin-based hybrid metal-organic frameworks(FTPs,as the core),including photodynamic/chemodynamic-like,catalase-like and glutathione peroxidase-like activities.Meanwhile,owing to the advantages of long circulation abilities of RBCs provided by their cell membranes(RBCMs),FTP with a surface coated with RBCMs(FTP@RBCM)could enormously accumulate at tumor site to achieve remarkably enhanced therapeutic effi-ciency.Intriguingly,this ROS-mediated dynamic therapy was demonstrated to induce acute local inflammation and high immunogenic cancer death,which evoked a systemic antitumor immune response when combined with the newly identified T cell immunoglobulin and mucin-containing molecule 3(Tim-3)checkpoint blockade,leading to not only effective elimination of primary tumors but also an absco-pal effect of growth suppression of distant tumors.Therefore,such RBC-mimic nanocatalysts with multidimensional catalytic capacities might provide a promising new insight into synergistic cancer treatment.

Jiong Li;Sijia Wang;Xinyi Lin;Yanbing Cao;Zhixiong Cai;Jing Wang;Zhenxi Zhang;Xiaolong Liu;Ming Wu;Cuiping Yao

Key Laboratory of Biomedical Information Engineering of Ministry of Education,Institute of Biomedical Photonics and Sensing,School of Life Science and Technology,Xi'an Jiaotong University,Xi'an 710049,People's Republic of China;The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province,Mengchao Hepatobiliary Hospital of Fujian Medical University,Fuzhou 350025,People's Republic of China;Mengchao Med-X Center,Fuzhou University,Fuzhou 350116,People's Republic of China

纳微快报（英文）

[1]Jiong Li;Sijia Wang;Xinyi Lin;Yanbing Cao;Zhixiong Cai;Jing Wang;Zhenxi Zhang;Xiaolong Liu;Ming Wu;Cuiping Yao-.Red Blood Cell-Mimic Nanocatalyst Triggering Radical Storm to Augment Cancer Immunotherapy)[J].纳微快报（英文）,2022(04):15-28

Nanocatalyst,Augment,promosing,RBCM,oncotherapy,FTPs,RBCMs,absco

Red,Blood,Cell,Mimic,Triggering,Radical,Storm,Cancer,Immunotherapy,blood,cells,RBCs,have,recently,emerged,candidates,cancer,treatment,terms,relieving,hypoxia,inducing,oxidative,damage,against,but,they,are,still,far,from,satisfactory,due,their,limited,oxygen,transport,reactive,spe,cies,generation,tissue,Herein,artificial,designated,radical,storm,production,ability,were,developed,through,multidimensional,reactivity,pathways,proto,porphyrin,hybrid,metal,organic,frameworks,core,including,photodynamic,chemodynamic,like,catalase,glutathione,peroxidase,activities,Meanwhile,owing,advantages,long,circulation,abilities,provided,by,membranes,surface,coated,could,enormously,accumulate,site,achieve,remarkably,enhanced,therapeutic,effi,ciency,Intriguingly,this,ROS,mediated,was,demonstrated,induce,acute,local,inflammation,high,immunogenic,death,which,evoked,systemic,antitumor,immune,response,when,combined,newly,identified,immunoglobulin,mucin,containing,molecule,Tim,checkpoint,blockade,leading,only,effective,elimination,primary,tumors,also,pal,growth,suppression,distant,Therefore,such,mimic,nanocatalysts,catalytic,capacities,might,promising,insight,into,synergistic

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