典型文献
An excimer'ON-OFF'switch based on telomeric G-quadruplex and rGO for trace thrombin detection
文献摘要：
In the recent decade,GO has emerged as an amazing 2D nanomaterial for developing DNA-based biosen-sors due to its fluorescence quenching properties,whereas similar research based on rGO was reported rarely.Herein,a novel multi-pyrene functionalized G-rich DNA probe based on the screened rGO showed much higher fluorescence quenching efficiency and excimer emission than that of universal GO.Different from the universal thrombin detection of the G4-forming aptamer-TBA(GGTTGGTGTGGTTGG),the original telomeric sequence is used in this study.The excimer emission"ON-OFF"switch amplified the response of thrombin detection is as low as 50 units.Furthermore,for four pyrene moieties that are sited in a crowded steric circumstance,the melting temperature(Tm)values and molecular dynamics simulations showed a positive effect on duplex G-quadruplex or GDNA·cDNA stability,without disturbing its helix structure.
文献关键词：
中图分类号：
作者姓名：
Long Zhao;Farid Ahmed;Hai Xiong
作者机构：
Institute for Advanced Study,Shenzhen University,Shenzhen 518060,China;College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China
文献出处：
引用格式：
[1]Long Zhao;Farid Ahmed;Hai Xiong-.An excimer'ON-OFF'switch based on telomeric G-quadruplex and rGO for trace thrombin detection)[J].中国化学快报（英文版）,2022(09):4243-4247
A类：
biosen,GGTTGGTGTGGTTGG,sited,GDNA
B类：
An,excimer,ON,OFF,switch,telomeric,quadruplex,rGO,trace,thrombin,detection,In,recent,decade,has,emerged,amazing,2D,nanomaterial,developing,sors,due,fluorescence,quenching,properties,whereas,similar,research,was,reported,rarely,Herein,novel,multi,pyrene,functionalized,rich,probe,screened,showed,much,higher,efficiency,emission,than,that,universal,Different,from,G4,forming,aptamer,TBA,original,sequence,used,this,study,amplified,response,low,units,Furthermore,four,moieties,crowded,steric,circumstance,melting,temperature,Tm,values,molecular,dynamics,simulations,positive,effect,duplex,cDNA,stability,without,disturbing,helix,structure
AB值：
0.609629
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