典型文献
Functional Xeno Nucleic Acids for Biomedical Application
文献摘要：
Functional nucleic acids(FNAs)refer to a type of oligonucleotides with functions over the traditional genetic roles of nucleic acids,which have been widely applied in screening,sensing and imaging fields.However,the potential application of FNAs in biomedical field is still restricted by the unsatisfactory stability,biocompatibility,biodistribution and immunity of natural nucleic acids(DNA/RNA).Xeno nucleic acids(XNAs)are a kind of nucleic acid analogues with chemically modified sugar groups that possess improved biological properties,including improved biological stability,increased binding affinity,reduced immune responses,and enhanced cell penetration or tissue specificity.In the last two decades,scientists have made great progress in the research of functional xeno nucleic acids,which makes it an emerging attractive biomedical application material.In this review,we summarized the design of functional xeno nucleic acids and their applications in the biomedical field.
文献关键词：
中图分类号：
作者姓名：
TU Tingting;HUAN Shuangyan;KE Guoliang;ZHANG Xiaobing
作者机构：
State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,P.R.China
文献出处：
引用格式：
[1]TU Tingting;HUAN Shuangyan;KE Guoliang;ZHANG Xiaobing-.Functional Xeno Nucleic Acids for Biomedical Application)[J].高等学校化学研究（英文版）,2022(04):912-918
A类：
FNAs,XNAs
B类：
Functional,Xeno,Nucleic,Acids,Biomedical,Application,nucleic,acids,refer,type,oligonucleotides,functions,over,traditional,genetic,roles,which,have,been,widely,applied,screening,sensing,imaging,fields,However,potential,biomedical,still,restricted,by,unsatisfactory,stability,biocompatibility,biodistribution,immunity,natural,are,kind,analogues,chemically,modified,sugar,groups,that,possess,improved,biological,properties,including,increased,binding,affinity,reduced,immune,responses,enhanced,cell,penetration,tissue,specificity,In,last,two,decades,scientists,made,great,progress,research,functional,xeno,makes,emerging,attractive,material,this,review,summarized,design,their,applications
AB值：
0.616845
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