典型文献
Helical Nonfouling Polypeptides for Biomedical Applications
文献摘要：
Synthetic polypeptides,also known as poly(α-amino acid)s(PαAAs),are biomimetic and biodegradable polymers holding great potential for a variety of biomedical applications.Possessing the same peptide bonds as natural proteins,polypeptides can also adopt typical well-defined secondary structures including α-helix,which have been shown to significantly impact the physicochemical properties and biological outcomes of materials.In this feature article,we review the state-of-the-art progresses of α-helical polypeptides for biomedical applications,with a special emphasis on the manipulation of helix-to-coil dynamic transition,conformation-associated anti-biofouling coatings,cellular uptake regulation,and reducing immunogenicity of polypeptide-protein conjugates.Finally,perspectives on outstanding challenges remained in this field and some important future directions are discussed.
文献关键词：
中图分类号：
作者姓名：
Chong Zhang;Hua Lu
作者机构：
Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen 518055,China;Beijing National Laboratory for Molecular Sciences,Center for Soft Matter Science and Engineering,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China
文献出处：
引用格式：
[1]Chong Zhang;Hua Lu-.Helical Nonfouling Polypeptides for Biomedical Applications)[J].高分子科学（英文版）,2022(05):433-446
A类：
Nonfouling,Polypeptides,Possessing
B类：
Helical,Biomedical,Applications,Synthetic,polypeptides,also,known,amino,acid,AAs,are,biomimetic,biodegradable,polymers,holding,great,potential,variety,biomedical,applications,same,bonds,natural,proteins,adopt,typical,well,defined,secondary,structures,including,helix,which,have,been,shown,significantly,impact,physicochemical,properties,biological,outcomes,materials,In,this,feature,article,review,state,progresses,helical,special,emphasis,manipulation,coil,dynamic,transition,conformation,associated,anti,biofouling,coatings,cellular,uptake,regulation,reducing,immunogenicity,conjugates,Finally,perspectives,outstanding,challenges,remained,field,some,important,future,directions,discussed
AB值：
0.705793
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