典型文献
Trimetaphosphate-induced chiral selection between amino acid and nucleoside using 15N-31P coupling NMR
文献摘要：
Life on Earth uses a common set of L-amino acids(L-aa)to construct proteins and D-nucleosides(d-Nu)to form nucleic acids,which serve as the carrier of genetic information.Herein,we reveal the in-trinsic mechanism of chiral selection of L-aa and D-Nu from the perspective of chemical origin of life.This work employed 15N-labeled L-aa and performed one-pot synthesis of nucleotide amidate of amino acid(N-aa-NMP)using equal amounts of L-15N-aa and D-14N-aa with D-/L-Nu in the aqueous solution of trimetaphosphate,generating L-15N-aa-NMP and D-14N-aa-NMP,respectively.The 31P-NMR data indicated that L-aa was preferentially selected during the formation of N-aa-NMP in the presence of D-Nu.Surpris-ingly,D-aa was preferred over L-aa in the presence of L-Nu.Further analysis revealed that L-15N-aa-D-NMP vs.D-14N-aa-L-NMP and D-14N-aa-D-NMP vs.L-15N-aa-L-NMP were mirror isomers of each other,respec-tively.These data suggest that there could be a set of chiral systems opposite to that on Earth,which infers there might be a world of life that is a mirror image of the Earth.
文献关键词：
中图分类号：
作者姓名：
Jianxi Ying;Ruiwen Ding;Yumeng Zhang;Bowen Han;Yeting Guo;Ning Wang;Dandan Guo;Yile Wu;Junwei Huang;Yan Liu;Feng Ni;Shaohua Huang;Yufen Zhao
作者机构：
Institute of Drug Discovery Technology,Ningbo University,Ningbo 315211,China;Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences,Ningbo University,Ningbo 315211,China;Department of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China;Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,China
文献出处：
引用格式：
[1]Jianxi Ying;Ruiwen Ding;Yumeng Zhang;Bowen Han;Yeting Guo;Ning Wang;Dandan Guo;Yile Wu;Junwei Huang;Yan Liu;Feng Ni;Shaohua Huang;Yufen Zhao-.Trimetaphosphate-induced chiral selection between amino acid and nucleoside using 15N-31P coupling NMR)[J].中国化学快报（英文版）,2022(02):821-824
A类：
Trimetaphosphate,amidate,trimetaphosphate,Surpris
B类：
induced,chiral,selection,between,amino,using,15N,31P,coupling,NMR,Life,Earth,uses,common,set,acids,aa,construct,proteins,nucleosides,Nu,nucleic,which,serve,carrier,genetic,information,Herein,trinsic,mechanism,from,perspective,chemical,origin,life,This,work,employed,labeled,performed,one,pot,synthesis,nucleotide,NMP,equal,amounts,14N,aqueous,solution,generating,respectively,data,indicated,that,was,preferentially,selected,during,presence,ingly,preferred,over,Further,analysis,revealed,were,mirror,isomers,each,other,These,suggest,there,could,systems,opposite,infers,might,world,image
AB值：
0.44295
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