典型文献
Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
文献摘要：
Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking,intercellular transport and the egress of unwanted proteins.They have been implicated in many diseases including cancer and neurodegeneration.EVs are detected in all bodily fluids,and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated.As such,they provide opportunities in biomarker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective monitor-ing of therapies.The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application,and multiplexing platforms have evolved with the potential to achieve this.Herein,we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis,with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency.
文献关键词：
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作者姓名：
Cheng Jiang;Ying Fu;Guozhen Liu;Bowen Shu;Jason Davise;George K.Tofaris
作者机构：
Nuffield Department of Clinical Neurosciences,New Biochemistry Building,University of Oxford,Oxford OX13QU,UK;Department of Chemistry,University of Oxford,Oxford OX13QZ,UK;Kavli Institute for Nanoscience Discovery,New Biochemistry Building,University of Oxford,Oxford,UK;School of Life and Health Sciences,The Chinese University of Hong Kong,Shenzhen 518172,People's Republic of China;Dermatology Hospital,Southern Medical University,Guangzhou 510091,People's Republic of China
文献出处：
引用格式：
[1]Cheng Jiang;Ying Fu;Guozhen Liu;Bowen Shu;Jason Davise;George K.Tofaris-.Multiplexed Profiling of Extracellular Vesicles for Biomarker Development)[J].纳微快报（英文）,2022(01):59-94
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assaying
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0.7024
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