Chiral properties of biological surface is of importance as they dominate interactions with biomolecules(such as proteins,nucleic acids,hormones)in a living system.Inspired by this phenomenon,we designed and constructed a L-/D-N-acetyl-cysteine-pillar[6]arene functionalized Si surface(L-/D-NACP surface)for studying the influence of superficial chirality on selective adsorption of R-adrenaline.The fabricated chiral L-/D-NACP surface with consistency in hydrophilia and elementary composition exhibited a strong mirror-symmetric circular dichroism signal.In the adsorption study,the contact-angle of R-adrenaline droplet on D-NACP surface was more hydrophilic from macroscopical view,and the size and quantity of R-adrenaline aggregation on D-NACP surface was larger than L-NACP surface,implying selective adsorption of R-adrenaline appeared on the D-NACP surface.The possible mechanism was due to the stronger host-guest interaction between D-NACP and R-adrenaline,which facilitated the selective adsorption.Besides,the D-NACP surface with good selectivity can be used for chiral separation of racemic adrenaline.The results enhance the under-standing of hormones adsorption affected by surface chirality,and may provide some helpful inspiration for practical application of chiral surface.

Ming Cheng;Wen Gong;Mingxiang Lu;Junkai Ma;Zhiyan Lu;Haibing Li

Key Laboratory of Pesticide and Chemical Biology(CCNU),Ministry of Education,College of Chemistry,Central China Normal University,Wuhan,Hubei 430079,China;Department of Cardiology,The Third People's Hospital of Hubei Province Hospital of Hubei Province,Wuhan,Hubei 430030,China;Department of Forensic Medicine,Zhongnan Hospital of Wuhan University,No.169 East Lake Road,Wuchang District,Wuhan,Hubei 430071,China;Hubei Key Laboratory of Wudang Local Chinese Medicine Research,Department of Chemistry,School of Pharmacy,Hubei University of Medicine,Shiyan,Hubei 442000,China

中国化学（英文版）

[1]Ming Cheng;Wen Gong;Mingxiang Lu;Junkai Ma;Zhiyan Lu;Haibing Li-.Engineering and Application of Pillar[6]arene Functionalized Chiral Surface in Selective Adsorption of R-Adrenaline)[J].中国化学（英文版）,2022(08):925-930

hydrophilia

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