Numerous strategies for linking desired chemical probes with target peptides and proteins have been developed and applied in the field of biological chemistry.Approaches for site-specific modification of native amino acid residues in test tubes and biological contexts represent novel biological tools for under-standing the role of peptides and proteins.Selective N-terminal modification strategies have been broadly studied especially in the last 10 years,as N-terminal positions are typically solvent exposed and provide chemically distinct sites for many peptide and protein targets,making N terminus distinct from other functional groups.A growing number of chemical and enzymatic techniques have been developed to modify N-terminal amino acids,and those techniques have the potential in the fields of medicine,ba-sic research and applied materials science.This review focuses on appraising modification methodologies with the potential for biological applications from the past 10 years.

Hongfei Jiang;Wujun Chen;Jie Wang;Renshuai Zhang

The Affiliated Hospital of Qingdao University and Qingdao Cancer Institute,Qingdao 266071,China

中国化学快报（英文版）

[1]Hongfei Jiang;Wujun Chen;Jie Wang;Renshuai Zhang-.Selective N-terminal modification of peptides and proteins:Recent progresses and applications)[J].中国化学快报（英文版）,2022(01):80-88

appraising

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