典型文献
Biological and mechanical investigation of novel flax/silk protein-based nanofibrous scaffold for bone regeneration
文献摘要：
The process of bone tissue regeneration involves an intricate network of a biological macromolecules that includes proteins and peptides to support stimulation and healing response.Here,we have fabricated a novel flaxseed/silk fibroin based(dual protein)composite nanofibers using β-TCP to improve the biological properties and promote cartilage tissue regeneration along with a controllable rate of biodegradation.The physiochemical properties of PVA/β-TCP/FP:SF were characterized by FTIR,XRD,SEM,porosity,contact angle measurements and mechanical evaluation etc.This study demonstrates the biological performance of the developed nanofibers by using hemocompatibility,biodegradation ability,and apatite deposition in stimulated body fluid.Moreover,the cell viability assay was performed on MG-63 osteoblast cells and long-term antibacterial rate against E.coli and S.aureus was analysed.Docking results of flax protein and silk fibroin protein further confirmed the stable modes of intramolecular bonding and the most stable electrostatic values using theoretical calculations.Taken together,the experimental results proved that the dual protein-based fibrous scaffold was found to be up-regulated in terms of biological activity with enhanced cell adhesion and proliferation.
文献关键词：
中图分类号：
作者姓名：
M.Rama;U.Vijayalakshmi
作者机构：
Department of Chemistry,School of Advanced Sciences,Vellore Institute of Technology,Vellore,632014,India
文献出处：
引用格式：
[1]M.Rama;U.Vijayalakshmi-.Biological and mechanical investigation of novel flax/silk protein-based nanofibrous scaffold for bone regeneration)[J].自然科学进展·国际材料（英文）,2022(04):443-455
A类：
B类：
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AB值：
0.632829
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