典型文献
Degradation and biological performance of porous osteomimetic biphasic calcium phosphate in vitro and in vivo
文献摘要：
The combination between biphasic calcium phosphate (BCP) and the osteomimetic porous micro-structure obtained via freeze casting is hoped to achieve excellent bone regeneration,while the effects of HA and β-TCP ratio changes on the degradation and biological performance of the BCP scaffolds with this unique micro-structure need to be determined.Here,we prepared the osteomimetic BCP scaffolds with different HA/β-TCP ratios (HA30/β-TCP70,HA50/β-TCP50,HA70/β-TCP30)and the effects of different HA/β-TCPHA/β-TCP ratios on the degradation and biological performance were studied in vitro and vivo.These BCP scaffolds with different HA/β-TCP ratios exhibited similar microstructure,mechanical performance,and protein absorption capability,while HA70/β-TCP30 BCP scaffolds showed an advisable degradation rate.Study in vitro confirmed the bio-com-patibility and promotion on the proliferation,differentia-tion of MG63 cells in the porous osteomimetic BCP scaffolds with a HA/β-TCP ratio at 30∶70.Implantation experiments also showed that the porous osteomimetic BCP scaffolds with a HA/β-TCP ratio at 30∶70 had excellent bone regeneration capacity and proper degrada-tion rate compatible with bone growth.These results reveal that the porous osteomimetic BCP scaffold with a HA/β-TCP ratio at 30∶70 is a potential candidate of biodegradable bone substitutes used for bone repair.
文献关键词：
中图分类号：
作者姓名：
Chun-Sheng Shao;Liang-Jian Chen;Rui-Min Tang;Bo Zhang;Jiang-Jie Tang;Wei-Na Ma
作者机构：
Department of Stomatology,Third Xiangya Hospital,Central South University,Changsha 410013,China
文献出处：
引用格式：
[1]Chun-Sheng Shao;Liang-Jian Chen;Rui-Min Tang;Bo Zhang;Jiang-Jie Tang;Wei-Na Ma-.Degradation and biological performance of porous osteomimetic biphasic calcium phosphate in vitro and in vivo)[J].稀有金属（英文版）,2022(02):457-468
A类：
osteomimetic,HA30,TCP70,HA50,TCP50,HA70,TCP30,TCPHA
B类：
Degradation,biological,performance,porous,biphasic,calcium,phosphate,vitro,vivo,combination,between,BCP,obtained,via,freeze,casting,hoped,achieve,excellent,bone,regeneration,while,effects,changes,degradation,scaffolds,this,unique,need,determined,Here,prepared,ratios,were,studied,These,exhibited,similar,microstructure,mechanical,protein,absorption,capability,showed,advisable,rate,Study,confirmed,patibility,promotion,proliferation,differentia,MG63,cells,Implantation,experiments,also,that,had,capacity,proper,compatible,growth,results,reveal,potential,candidate,biodegradable,substitutes,used,repair
AB值：
0.358791
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