典型文献
L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing
文献摘要：
Nowadays,there are still many challenges to skin regeneration.As a new type of skin substitute,hydro-gel has emerging gradually with its excellent properties.However,it is still a challenge to combine with biological active agents to facilitate skin regeneration.Under the circumstance,we synthesized arginine-based poly(ester amide)(Arg-PEA)and hyaluronic acid(HA-MA),and combined them into new hybrid hydrogels via photo-crosslinking.We found that the internal structure and physicochemical properties of hybrid hydrogels were greatly improved with the increase of content of Arg-PEA.Therefore,we designed hybrid hydrogels with 5 wt％and 10 wt％of Arg-PEA content,respectively.Besides,we selected the corre-sponding anti-inflammatory(CRP,TNF-α)indicators to detect the anti-inflammatory properties of the hy-brid hydrogels at the protein level,and the corresponding antioxidant indicators(SOD,GSH/GSSG,MDA)were selected to investigate the antioxidant properties of hybrid hydrogels at the cellular level in vitro.In addition,we also selected relevant genes to test the effect of hybrid hydrogels on fibrosis and vascu-larization in the process of skin wound healing in vitro and verified them in vivo with a mouse dorsum wound model.The results confirmed that Arg-PEA/HA-MA(AH)hybrid hydrogel was a prospective scaf-fold material for skin regeneration.
文献关键词：
中图分类号：
作者姓名：
Tong Liu;Guiting Liu;Jianhua Zhang;Zhangfan Ding;Yike Li;Krishna Sigdel;Xiaoyi Wang;Huixu Xie
作者机构：
State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Head and Neck Oncology Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;The State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu 610065,China;College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China
文献出处：
引用格式：
[1]Tong Liu;Guiting Liu;Jianhua Zhang;Zhangfan Ding;Yike Li;Krishna Sigdel;Xiaoyi Wang;Huixu Xie-.L-Arginine based polyester amide/hyaluronic acid hybrid hydrogel with dual anti-inflammation and antioxidant functions for accelerated wound healing)[J].中国化学快报（英文版）,2022(04):1880-1884
A类：
scaf
B类：
Arginine,polyester,amide,hyaluronic,acid,hybrid,inflammation,antioxidant,functions,accelerated,wound,healing,Nowadays,there,are,still,many,challenges,skin,regeneration,new,type,substitute,has,emerging,gradually,its,excellent,properties,However,biological,active,agents,facilitate,Under,circumstance,synthesized,arginine,PEA,HA,MA,combined,them,into,hydrogels,via,photo,crosslinking,We,found,that,internal,structure,physicochemical,were,greatly,improved,increase,content,Therefore,designed,wt,respectively,Besides,selected,inflammatory,indicators,detect,protein,level,corresponding,GSH,GSSG,investigate,cellular,vitro,In,addition,also,relevant,genes,test,effect,fibrosis,vascu,larization,process,verified,vivo,mouse,dorsum,model,results,confirmed,AH,was,prospective,fold,material
AB值：
0.485403
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
