典型文献
High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma
文献摘要：
Multiple myeloma (MM) is a common malig-nant hematological tumor in adults, which is charac-terized by clonal malignant proliferation of plasma cells in the bone marrow and secretion of a large num-ber of abnormal monoclonal immunoglobulins (M pro-tein), leading to bone destruction, hypercalcemia, an?emia, and renal insufficiency (Alexandrakis et al., 2015;Yang et al., 2018). Since a large number of new drugs, represented by proteasome inhibitors and im-munomodulators, have been successfully used to treat MM, treatment efficacy and survival of patients have been significantly improved. However, due to the high heterogeneity of this disease, patients have responded differently to treatments with these new drugs (Pa-lumbo and Anderson, 2011;Wang et al., 2016;Huang et al., 2020). Growth and survival of MM cells de-pend on the bone marrow microenvironment, espe-cially numerous inflammatory cytokines secreted by myeloma cells and bone marrow stromal cells, such as vascular endothelial growth factor (VEGF), inter-leukin (IL)-6, transforming growth factor-β (TGF-β), and IL-10. These cytokines can promote the growth of myeloma cells, induce angiogenesis, and inhibit antitumor immunity, and are often linked to patient prognosis (Kumar et al., 2017).
文献关键词：
中图分类号：
作者姓名：
Xiaoyan YUE;Linlin HUANG;Yang YANG;Yi ZHAO;Donghua HE;Xiaoyan HAN;Gaofeng ZHENG;Yi LI;Enfan ZHANG;Zhen CAI;Xin HUANG;Jingsong HE
作者机构：
Bone Marrow Transplantation Center,Department of Hematology,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;Institute of Hematology,Zhejiang University,Hangzhou 310058,China;Zhejiang Laboratory for Systems&Precision Medicine,Zhejiang University Medical Center,Hangzhou 311121,China;Institute of Hematology,Department of Hematology,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China
引用格式：
[1]Xiaoyan YUE;Linlin HUANG;Yang YANG;Yi ZHAO;Donghua HE;Xiaoyan HAN;Gaofeng ZHENG;Yi LI;Enfan ZHANG;Zhen CAI;Xin HUANG;Jingsong HE-.High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(11):968-974,16-19
A类：
emia,Alexandrakis,munomodulators,lumbo
B类：
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AB值：
0.565671
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