典型文献
Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening
文献摘要：
Dear Editor,
The Coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The genome of this virus encodes two overlapping polyproteins,pp1 a and pp1ab(Wu et al.,2020;Zhou et al.,2020).The functional polypeptides are released from those two polyproteins by extensive proteolytic events,mostly mediated by main protease(Mpro,also known as 3CLpro).It cleaves the polyproteins at no less than 11 conserved sites to produce non-structure proteins(Nsps)(Wu et al.,2020),and no human protease has been found to share similar cleavage specificity(Wu et al.,2020).Since these cleavage events play an essential role in viral replication and pathogenesis,Mpro is considered as one of the most attractive targets for drugs development to combat the ongoing COVID-19 pandemic(Pillaiyar et al.,2016).
文献关键词：
中图分类号：
作者姓名：
Yuan Zhang;Chunjie Li;Xianliang Ke;Dan Luo;Yan Liu;Quanjiao Chen;Hanzhong Wang;Xiaohui Song;Zhenhua Zheng
作者机构：
Key Laboratory of Special Pathogens and Biosafety,Center for Emerging Infectious Diseases,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China;University of the Chinese Academy of Sciences,Beijing,100049,China;Department of Gastroenterology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan,430015,China;Department of Obstetrics,Wuhan Children's Hospital,Wuhan Maternal and Child Healthcare Hospital,Tongji Medical College,Huazhong University of Science&Technology,Wuhan,430015,China
文献出处：
引用格式：
[1]Yuan Zhang;Chunjie Li;Xianliang Ke;Dan Luo;Yan Liu;Quanjiao Chen;Hanzhong Wang;Xiaohui Song;Zhenhua Zheng-.Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening)[J].中国病毒学,2022(03):459-461
A类：
polyproteins,pp1,pp1ab,cleaves,Nsps,Pillaiyar
B类：
Development,biosensor,assessing,SARS,CoV,main,protease,proteolytic,activity,living,cells,antiviral,drugs,screening,Dear,Editor,
The,Coronavirus,disease,pandemic,caused,by,severe,acute,respiratory,syndrome,coronavirus,genome,this,encodes,two,overlapping,Wu,Zhou,functional,polypeptides,released,from,those,extensive,events,mostly,mediated,Mpro,also,known,3CLpro,It,less,than,conserved,sites,produce,structure,human,has,been,found,share,similar,cleavage,specificity,Since,these,play,essential,role,replication,pathogenesis,considered,one,attractive,targets,development,combat,ongoing
AB值：
0.550903
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
