Folic acid belongs to the group of water-soluble B vitamins and naturally exists in multiple forms in a wide variety of foods such as legumes, vegetables, liver, and milk (Iyer and Tomar, 2009; Lyon et al., 2020). It is involved in many biochemical reactions critical for cell division, such as purine and pyrimi-dine biosynthesis, DNA/RNA biosynthesis, and amino acid metabolism (Iyer and Tomar, 2009). Mammals cannot synthesize folic acid and thus they must acquire it from food. Although folic acid is ubiquitous in foods, folic acid deficiency still often occurs due to various causes such as unhealthy diet (Hildebrand et al., 2021;Iimura et al., 2022), disease-related malabsorp-tion (Arcot and Shrestha, 2005), medication-related depletion (Arcot and Shrestha, 2005), or vitamin B12 deficiency (Fishman et al., 2000). Folic acid deficiency has been associated with several health problems, such as anemia (Carmel, 2005; Bailey and Caudill, 2012), cancer (Duthie, 1999), cardiovascular diseases (Wald et al., 2002), neural tube defects in newborns (van der Put et al., 2001), neuropsychiatric dysfunction (Shea et al., 2002), depression (Falade et al., 2021), inflam-matory diseases (Suzuki and Kunisawa, 2015; Jones et al., 2019), and eye diseases (Sijilmassi, 2019).

Qirong SHEN;Quan HE;Yuanjiang PAN;Cuirong SUN

College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Hangzhou Qianyuan Pollen Pharmaceutical Co.,Ltd.,Hangzhou 310018,China;Department of Chemistry,Zhejiang University,Hangzhou 310027,China

浙江大学学报（英文版）（B辑：生物医学和生物技术）

[1]Qirong SHEN;Quan HE;Yuanjiang PAN;Cuirong SUN-.Detection, isolation, and characterization of a novel impurity from several folic acid products)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(07):597-606,中插30-中插47

Iyer,Tomar,pyrimi,Mammals,Iimura,malabsorp,Arcot,Shrestha,Fishman,Carmel,Caudill,Shea,Falade,Kunisawa,Sijilmassi

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