典型文献
Transcriptional control of pancreatic β-cell identity and plasticity during the pathogenesis of type 2 diabetes
文献摘要：
Type 2 diabetes(T2D)is caused by insulin resistance and insufficient insulin secretion.Evidence has increasingly indicated that pancreatic β-cell dysfunction is the primary determinant of T2D disease pro-gression and remission.High plasticity is an important feature of pancreaticβ-cells.During T2D develop-ment,pancreatic β-cells undergo dynamic adaptation.Although β-cell death/apoptosis in later-stage T2D is the major cause of β-cell dysfunction,recent studies have revealed that β-cell dedifferentiation and reprogramming,which play critical roles in β-cell functional regulation in the early and middle T2D pro-gression stages,are characterized by(ⅰ)a loss of mature β-cell-enriched genes;(ⅱ)dedifferentiation to a progenitor-like state;and(ⅲ)transdifferentiation into other cell types.The roles of transcription factors(TFs)in the establishment and maintenance of β-cell identity during pancreatic development have been exten-sively studied.Here,we summarize the roles and underlying mechanisms of TFs in the maintenance of β-cell identity under physiological and type 2 diabetic conditions.Several feasible approaches for restoring islet functions are also discussed.A better understanding of the transcriptional control of β-cell identity and plasticity will pave the way for developing more effective strategies,such as β-cell regeneration therapy,to treat T2D and associated metabolic disorders.
文献关键词：
中图分类号：
作者姓名：
Ziyin Zhang;Yue Gao;Zhuo-Xian Meng
作者机构：
Department of Pathology and Pathophysiology and Department of Geriatrics of Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,China;Key Laboratory of Disease Proteomics of Zhejiang Province,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310058,China;Department of Geriatrics,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310006,China
文献出处：
引用格式：
[1]Ziyin Zhang;Yue Gao;Zhuo-Xian Meng-.Transcriptional control of pancreatic β-cell identity and plasticity during the pathogenesis of type 2 diabetes)[J].遗传学报,2022(04):316-328
A类：
B类：
Transcriptional,control,pancreatic,identity,plasticity,during,pathogenesis,diabetes,Type,T2D,caused,by,insulin,resistance,insufficient,secretion,Evidence,has,increasingly,indicated,that,dysfunction,primary,determinant,disease,gression,remission,High,important,feature,cells,During,undergo,dynamic,adaptation,Although,death,apoptosis,later,major,recent,studies,have,revealed,dedifferentiation,reprogramming,which,play,critical,roles,functional,regulation,early,middle,stages,are,characterized,loss,mature,enriched,progenitor,like,state,transdifferentiation,into,other,types,factors,TFs,establishment,maintenance,development,been,exten,sively,studied,Here,we,summarize,underlying,mechanisms,physiological,diabetic,conditions,Several,feasible,approaches,restoring,islet,functions,also,discussed,better,understanding,transcriptional,will,pave,way,developing,more,effective,strategies,such,regeneration,therapy,treat,associated,metabolic,disorders
AB值：
0.604595
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