典型文献
Therapeutic potential of translocator protein ligands for age-related macular degeneration
文献摘要：
Age-related macular degeneration: Age-related macular degeneration (AMD) is a retinal degenerative disorder, characterized by the irreversible loss of the central vision during ageing. This chronic, progressive disease has been estimated to currently affect around 196 million people worldwide and will increase to 288 million in 2040 (Wong, et al., 2014). Early AMD is defined by the presence of drusen underneath the retinal pigment epithelial (RPE) layer. Late AMD can be divided into two groups, "wet AMD" and "dry AMD", depending on the underlying clinical features. Wet AMD demonstrates a clinic feature of choroidal neovascularization (CNV) in which new blood vessels protrude from the choroid through the Bruch's membrane and interfere with the morphological architecture of RPE and the superficial retina. Wet AMD accounts for approximately 10％ of AMD patients, but for around 90％ of resultant blind registration. Targeting vascular endothelial growth factor treatment greatly suppresses CNV progression in most wet AMD patients. Dry AMD is characterized by geographic atrophy and no effective therapy is available for dry AMD patients (Pikuleva and Curcio, 2014; Wong et al., 2014).
文献关键词：
中图分类号：
作者姓名：
Xing Li
作者机构：
School of Basic Medical Sciences,Shaoyang University,Shaoyang,Hunan Province,China;Department of Biological and Biomedical Sciences,Department of Vision Science,Glasgow Caledonian University,Glasgow,UK
文献出处：
引用格式：
[1]Xing Li-.Therapeutic potential of translocator protein ligands for age-related macular degeneration)[J].中国神经再生研究（英文版）,2022(04):793-794
A类：
drusen,protrude,Pikuleva,Curcio
B类：
Therapeutic,potential,translocator,protein,ligands,related,macular,degeneration,Age,AMD,retinal,degenerative,disorder,characterized,by,irreversible,loss,central,vision,during,ageing,This,chronic,progressive,disease,has,been,estimated,currently,affect,around,million,people,worldwide,will,increase,Wong,Early,defined,presence,underneath,pigment,epithelial,RPE,layer,Late,can,divided,into,two,groups,wet,dry,depending,underlying,clinical,features,Wet,demonstrates,choroidal,neovascularization,CNV,which,new,blood,vessels,from,through,Bruch,membrane,interfere,morphological,architecture,superficial,accounts,approximately,patients,but,resultant,blind,registration,Targeting,endothelial,growth,treatment,greatly,suppresses,progression,most,Dry,geographic,atrophy,no,effective,therapy,available
AB值：
0.58142
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