典型文献
Protection from infection or disease?Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines
文献摘要：
How do we measure vaccine efficacy?The strictest but also easiest parameter to determine vaccine efficacy is its ability to block infection.Indeed,if a vaccine is able to block infection,this necessarily follows that it will also prevent both disease development and viral transmission.As a consequence,antibodies,specifically neutralising antibodies,have been used as the"gold standard"correlate of protection to measure SARS-CoV-2 vaccine efficacy,given their ability to block infection.Since SARS-CoV-2 infects cells by the binding of its spike protein to the host ACE-2 receptor,a vaccine that is able to induce a large quantity of antibodies able to block the interaction between the ACE-2 receptor and spike protein should theoretically be highly efficacious.Given this"antibody-centric"method of evaluating of a vaccine,it is clear why spike mRNA vaccines have to date been regarded the most effective COVID-19 vaccine in the market.
文献关键词：
中图分类号：
作者姓名：
Anthony T.Tan;Joey Ming Er Lim;Antonio Bertoletti
作者机构：
Programme in Emerging Infectious Diseases,Duke-NUS Medical School,Singapore,169857,Singapore;Singapore Immunology Network,A*STAR,Singapore,138648,Singapore
文献出处：
引用格式：
[1]Anthony T.Tan;Joey Ming Er Lim;Antonio Bertoletti-.Protection from infection or disease?Re-evaluating the broad immunogenicity of inactivated SARS-CoV-2 vaccines)[J].中国病毒学,2022(06):783-785
A类：
easiest,neutralising
B类：
Protection,from,infection,disease,Re,evaluating,broad,immunogenicity,inactivated,SARS,CoV,vaccines,How,do,measure,efficacy,strictest,but,also,parameter,determine,its,ability,block,Indeed,able,this,necessarily,follows,that,will,prevent,both,development,viral,transmission,consequence,antibodies,specifically,have,been,used,gold,standard,correlate,protection,given,their,Since,infects,cells,by,binding,spike,protein,host,ACE,receptor,induce,large,quantity,interaction,between,should,theoretically,highly,efficacious,Given,antibody,centric,method,clear,why,date,regarded,most,effective,market
AB值：
0.546083
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