典型文献
A pair of SARS-CoV-2 nucleocapsid protein monoclonal antibodies shows high specificity and sensitivity for diagnosis
文献摘要：
Dear Editor,
Severe Acute Respiratory Syndrome Coronavirus Type 2(SARS-CoV-2)is the pathogen of the coronavirus disease 2019(COVID-19),which has spread worldwide.
SARS-CoV-2 is an enveloped virus belongs to the family of p-coro-navirus(Xu et al.,2020).Its genome is a linear single-stranded pos-itive-sense RNA about 30,000 nucleotides packed inside a virion with a diameter of 100 nm and a volume of about 106 nm3(Bar-On et al.,2020).The genome of SARS-CoV-2 encodes 29 proteins,including 16 nonstructural,four structural,and nine accessory proteins(Bai et al.,2021).The four structural proteins are spike(S)glycoprotein,envelope(E)protein,membrane(M)protein,and nucleocapsid(N)protein(Naqvi et al.,2020),which are shared with other coronaviruses(Brian and Baric,2005;Fehr and Perlman,2015).S glycoprotein is essential for viral infection while N protein facilitates viral RNA packing,replication,virion assembly,and release(Almazán et al.,2004;Peng et al.,2020).SARS-CoV-2 has 96％identity to bats coronaviruses and 91％identity to pangolins coronaviruses in nucleic acid sequence.In contrast,its nucle-otide homology to SARS-CoV-1 is 80％,to Middle East Respiratory Syn-drome(MERS)Coronavirus(MERS-CoV)is 55％(Bar-On et al.,2020;Zhou et al.,2020).Due to its error-prone RNA dependent RNA poly-merase(RdRp),mutation rate of SARS-CoV-2 is relatively high(Ludwig and Zarbock,2020).Accordingly,multiple strains of SARS-CoV-2 have emerged,such as Alpha,Beta,Gamma,Delta,and Omicron,etc.
文献关键词：
中图分类号：
作者姓名：
An-Kai Zhu;Sa-Sa Li;Shu-Pei Yu;Zhao-Yong Zhang;Huan Li;Jing-Feng Li;Shan-Shan Gao;Heng Chen;Jincun Zhao;Run Shi;Mingjian Lu;Chaoyang Li
作者机构：
Affiliated Cancer Hospital and Institute of Guangzhou Medical University,State Key Laboratory of Respiratory Disease,Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong High Education Institute,Guangzhou,510095,China;State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510182,China;Department of Interventional Radiology,Affiliated Cancer Hospital and Institute of Guangzhou Medical University,Guangzhou,510095,China
文献出处：
引用格式：
[1]An-Kai Zhu;Sa-Sa Li;Shu-Pei Yu;Zhao-Yong Zhang;Huan Li;Jing-Feng Li;Shan-Shan Gao;Heng Chen;Jincun Zhao;Run Shi;Mingjian Lu;Chaoyang Li-.A pair of SARS-CoV-2 nucleocapsid protein monoclonal antibodies shows high specificity and sensitivity for diagnosis)[J].中国病毒学,2022(06):942-945
A类：
SARS,Naqvi,Baric,Fehr,Perlman,Almaz,pangolins,Zarbock
B类：
pair,CoV,nucleocapsid,monoclonal,antibodies,shows,high,specificity,sensitivity,diagnosis,Dear,Editor,
Severe,Acute,Respiratory,Syndrome,Coronavirus,Type,pathogen,disease,which,has,spread,worldwide,enveloped,belongs,family,Xu,Its,genome,linear,single,stranded,pos,itive,sense,about,nucleotides,packed,inside,virion,diameter,volume,nm3,On,encodes,proteins,including,nonstructural,four,nine,accessory,Bai,spike,glycoprotein,membrane,shared,other,coronaviruses,Brian,essential,viral,infection,while,facilitates,packing,replication,assembly,release,Peng,identity,bats,nucleic,acid,sequence,In,contrast,its,homology,Middle,East,MERS,Zhou,Due,error,prone,dependent,poly,merase,RdRp,mutation,rate,relatively,Ludwig,Accordingly,multiple,strains,have,emerged,such,Alpha,Beta,Gamma,Delta,Omicron,etc
AB值：
0.518995
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
