典型文献
Laser ablation-single particle-inductively coupled plasma mass spectrometry as a sensitive tool for bioimaging of silver nanoparticles in vivo degradation
文献摘要：
The in vivo degradation behavior of metallic nanoparticles(NPs)is very important for their biomedical applications and safety evaluation.Here,a method of laser ablation-single particle inductively coupled plasma mass spectrometry(LA-sp-ICP-MS)is shown to have high spatial resolution,sensitivity and accu-racy for simultaneous imaging the in situ distribution of particulate Ag(P-Ag)and released ionic Ag(Ion-Ag)in the sub-organs of spleen,liver and kidney after intravenous injection of Ag nanoparticles(50 nm,AgNPs)to mice.Under the optimized parameters of 0.4 J/cm2 laser fluence on a 30 pm spot with dwell time at 100 ps,the signals of P-Ag and Ion-Ag in the organic tissues can be easily distinguished from the mass spectra.The method of iterative threshold algorithm has been used to distract the signals of P-Ag and Ion-Ag and separate each other.The resulting images for the first time provide visualized evidence that a considerable amount of P-Ag accumulated in the splenic marginal zone,but widely distributed in the liver parenchyma at 24 h after injection of AgNPs,and in the meantime,obvious amounts of ionic Ag released and distributed in the organs.In addition,the imaging results indicate that the AgNP excretion in the kidney is mainly in ionic forms.The investigation here demonstrates that the developed LA-sp-ICP-MS method with high spatial resolution,sensitivity and visualization capability can become a powerful tool in the clinical context of metallic NPs.
文献关键词：
中图分类号：
作者姓名：
Meng Wang;Lingna Zheng;Bing Wang;Pu Yang;Hao Fang;Shanshan Liang;Wei Chen;Weiyue Feng
作者机构：
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;University of Chinese Academy of Sciences,Beijing 100049,China
文献出处：
引用格式：
[1]Meng Wang;Lingna Zheng;Bing Wang;Pu Yang;Hao Fang;Shanshan Liang;Wei Chen;Weiyue Feng-.Laser ablation-single particle-inductively coupled plasma mass spectrometry as a sensitive tool for bioimaging of silver nanoparticles in vivo degradation)[J].中国化学快报（英文版）,2022(07):3484-3487
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B类：
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AB值：
0.55227
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