典型文献
Druggability of lipid metabolism modulation against renal fibrosis
文献摘要：
Renal fibrosis contributes to progressive damage to renal structure and function.It is a common pathological process as chronic kidney disease develops into kidney failure,irrespective of diverse etiologies,and eventually leads to death.However,there are no effective drugs for renal fibrosis treatment at present.Lipid aggregation in the kidney and consequent lipotoxicity always accompany chronic kidney disease and fibrosis.Numerous studies have revealed that restoring the defective fatty acid oxidation in the kidney cells can mitigate renal fibrosis.Thus,it is an important strategy to reverse the dysfunctional lipid metabolism in the kidney,by targeting critical regulators of lipid metabolism.In this review,we highlight the potential "druggability" of lipid metabolism to ameliorate renal fibrosis and provide current pre-clinical evidence,exemplified by some representative druggable targets and several other metabolic regulators with anti-renal fibrosis roles.Then,we introduce the preliminary progress of noncoding RNAs as promising anti-renal fibrosis drug targets from the perspective of lipid metabolism.Finally,we discuss the prospects and deficiencies of drug targeting lipid reprogramming in the kidney.
文献关键词：
中图分类号：
作者姓名：
Yuan-yuan Chen;Xiao-guang Chen;Sen Zhang
作者机构：
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union medical college,Beijing 100050,China
文献出处：
引用格式：
[1]Yuan-yuan Chen;Xiao-guang Chen;Sen Zhang-.Druggability of lipid metabolism modulation against renal fibrosis)[J].中国药理学报（英文版）,2022(03):505-519
A类：
Druggability,lipotoxicity,druggability
B类：
lipid,metabolism,modulation,against,renal,fibrosis,Renal,contributes,progressive,damage,structure,It,common,pathological,process,chronic,kidney,disease,develops,into,failure,irrespective,diverse,etiologies,eventually,leads,death,However,there,are,effective,drugs,treatment,Lipid,aggregation,consequent,always,accompany,Numerous,studies,have,revealed,that,restoring,defective,fatty,acid,oxidation,cells,can,mitigate,Thus,important,strategy,reverse,dysfunctional,by,targeting,critical,regulators,In,this,review,highlight,potential,ameliorate,provide,current,clinical,evidence,exemplified,some,representative,druggable,targets,several,other,metabolic,anti,roles,Then,introduce,preliminary,noncoding,RNAs,promising,from,perspective,Finally,discuss,prospects,deficiencies,reprogramming
AB值：
0.576475
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
