典型文献
Driving role of macrophages in transition from acute kidney injury to chronic kidney disease
文献摘要：
Acute kidney injury (AKI), characterized by acute renal dysfunction, is an increasingly common clinical problem and an important risk factor in the subsequent development of chronic kidney disease (CKD). Regardless of the initial insults, the progression of CKD after AKI involves multiple types of cells, including renal resident cells and immune cells such as macrophages. Recently, the involvements of macrophages in AKI-to-CKD transition have garnered significant attention. Furthermore, substantial progress has also been made in elucidating the pathophysiological functions of macrophages from the acute kidney to repair or fibrosis. In this review, we highlight current knowledge regarding the roles and mechanisms of macrophage activation and phenotypic polarization, and transdifferentiation in the development of AKI-to-CKD transition. In addition, the potential of macrophage-based therapy for preventing AKI-to-CKD transition is also discussed.
文献关键词：
Acute kidney injury;Chronic kidney disease;Macrophage;Inflammation;Repair;Macrophage-based therapy
中图分类号：
作者姓名：
Meng Xiaoming;Jin Juan;Lan Hui Yao
作者机构：
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhul Medical University, The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, Anhui 230032, China;School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China;Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China;The Chinese University of Hong Kong-Guangdong Academy of Sciences/Guangdong Provincial People’s Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, China
文献出处：
引用格式：
[1]Meng Xiaoming;Jin Juan;Lan Hui Yao-.Driving role of macrophages in transition from acute kidney injury to chronic kidney disease)[J].中华医学杂志（英文版）,2022(07):757-766
A类：
involvements
B类：
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AB值：
0.554346
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