典型文献
Understanding the mechanistic regulation of ferroptosis in cancer:the gene matters
文献摘要：
Ferroptosis has emerged as a crucial regulated cell death involved in a variety of physiological processes or pathological diseases,such as tumor suppression.Though initially being found from anticancer drug screening and considered not essential as apoptosis for growth and development,numerous studies have demonstrated that ferroptosis is tightly regulated by key genetic pathways and/or genes,including several tumor suppressors and oncogenes.In this review,we introduce the basic concepts of ferroptosis,char-acterized by the features of non-apoptotic,iron-dependent,and overwhelmed accumulation of lipid per-oxides,and the underlying regulated circuits are considered to be pro-ferroptotic pathways.Then,we discuss several established lipid peroxidation defending systems within cells,including SLC7A11/GPX4,FSP1/CoQ,GCH1/BH4,and mitochondria DHODH/CoQ,all of which serve as anti-ferroptotic pathways to prevent ferroptosis.Moreover,we provide a comprehensive summary of the genetic regulation of ferrop-tosis via targeting the above-mentioned pro-ferroptotic or anti-ferroptotic pathways.The regulation of pro-and anti-ferroptotic pathways gives rise to more specific responses to the tumor cells in a context-dependent manner,highlighting the unceasing study and deeper understanding of mechanistic regula-tion of ferroptosis for the purpose of applying ferroptosis induction in cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Min Gao;Kexin Fan;Yuhan Chen;Guangjian Zhang;Jing Chen;Yilei Zhang
作者机构：
The Institute of Molecular and Translational Medicine,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xi'an Jiaotong University Health Science Center,Xi'an,Shaanxi 710061,China;Department of Thoracic Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;Department of Obstetrics,Xi'an New Chang'an Maternity Hospital,Xi'an,Shaanxi 710001,China;Shaanxi Stem Cell Engineering Application Research Center,Shaanxi Jiuzhou Biomedical Science and Technology Group,Xi'an,Shaanxi 710065,China
文献出处：
引用格式：
[1]Min Gao;Kexin Fan;Yuhan Chen;Guangjian Zhang;Jing Chen;Yilei Zhang-.Understanding the mechanistic regulation of ferroptosis in cancer:the gene matters)[J].遗传学报,2022(10):913-926
A类：
CoQ,ferrop,unceasing
B类：
Understanding,mechanistic,regulation,ferroptosis,matters,Ferroptosis,has,emerged,crucial,regulated,death,involved,variety,physiological,processes,pathological,diseases,such,tumor,suppression,Though,initially,being,found,from,anticancer,drug,screening,considered,not,essential,apoptosis,growth,development,numerous,studies,have,demonstrated,that,tightly,by,key,genetic,pathways,including,several,suppressors,oncogenes,In,this,review,we,introduce,basic,concepts,char,acterized,features,apoptotic,iron,dependent,overwhelmed,accumulation,lipid,oxides,underlying,circuits,are,ferroptotic,Then,discuss,established,peroxidation,defending,systems,within,cells,SLC7A11,GPX4,FSP1,GCH1,BH4,mitochondria,DHODH,which,serve,prevent,Moreover,provide,comprehensive,summary,via,targeting,above,mentioned,gives,rise,more,specific,responses,context,manner,highlighting,study,deeper,understanding,purpose,applying,induction,therapy
AB值：
0.589349
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