典型文献
Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease
文献摘要：
Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease worldwide. It refers to a range of liver conditions affecting people who drink little or no alcohol. NAFLD comprises non-alcoholic fatty liver and non-alcoholic steatohepatitis (NASH), the more aggressive form of NAFLD. NASH is featured by steatosis, lobular inflammation, hepatocyte injury, and various degrees of fibrosis. Although much progress has been made over the past decades, the pathogenic mechanism of NAFLD remains to be fully elucidated. Hepatocyte nuclear factor 4α (HNF4α) is a nuclear hormone receptor that is highly expressed in hepatocytes. Hepatic HNF4α expression is markedly reduced in NAFLD patients and mouse models of NASH. HNF4α has been shown to regulate bile acid, lipid, glucose, and drug metabolism. In this review, we summarize the recent advances in the understanding of the pathogenesis of NAFLD with a focus on the regulation of HNF4α and the role of hepatic HNF4α in NAFLD. Several lines of evidence have shown that hepatic HNF4α plays a key role in the initiation and progression of NAFLD. Recent data suggest that hepatic HNF4α may be a promising target for treatment of NAFLD.
文献关键词：
Nonalcoholic fatty liver disease;Hepatocyte nuclear factor 4α;Lipogenesis;Inflammation;Fibrosis;Liver;Lipotoxicity;Apoptosis
中图分类号：
作者姓名：
Pan Xiaoli;Zhang Yanqiao
作者机构：
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA
文献出处：
引用格式：
[1]Pan Xiaoli;Zhang Yanqiao-.Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease)[J].中华医学杂志（英文版）,2022(10):1172-1181
A类：
Lipogenesis,Lipotoxicity
B类：
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AB值：
0.549872
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
