典型文献
Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies
文献摘要：
Nonalcoholic steatohepatitis(NASH),an inflammatory subtype of nonalcoholic fatty liver disease,is featured by significantly elevated levels of various proinflammatory cytokines.Among numerous proin-flammatory factors that contribute to NASH pathogenesis,the secreted protein,tumor necrosis factor-alpha(TNF-α),plays an essential role in multiple facets of NASH progression and is therefore considered as a potential therapeutic target.In this review,we will first systematically describe the preclinical studies on the biochemical function of TNF-α and its intracellular downstream signaling mechanisms through its re-ceptors.Moreover,we extensively discuss its functions in regulating inflammation,cell death,and fibrosis of liver cells in the pathogenesis of NASH,and the molecular mechanism that TNF-α expression is regulated by NF-κB and other upstream master regulators during NASH progression.As TNF-α is one of the causal factors that remarkably contributes to NASH progression,combination of therapeutic modalities,including TNF-α-based therapies may lead to the resolution of NASH via multiple pathways and thus generate clinical benefits.For translational studies,we summarize recent advances in strategies targeting TNF-α and its signaling pathway,which paves the way for potential therapeutic treatments for NASH in the future.
文献关键词：
中图分类号：
作者姓名：
Sijia Lu;Yibing Wang;Junli Liu
作者机构：
Shanghai Diabetes Institute,Department of Endocrinology and Metabolism,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China;School of Kinesiology,Shanghai University of Sports,Shanghai 200438,China
文献出处：
引用格式：
[1]Sijia Lu;Yibing Wang;Junli Liu-.Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies)[J].遗传学报,2022(04):269-278
A类：
ceptors
B类：
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AB值：
0.570783
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