Type 2 diabetes mellitus(T2DM)and nonalcoholic fatty liver disease(NAFLD)are the most problematic metabolic diseases in the world.NAFLD encompasses a spectrum of severity,ranging from simple steato-sis to non-alcoholic steatohepatitis(NASH)and fibrosis,increasing the risk of cirrhosis and hepatocellular carcinoma.Importantly,NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM.T2DM and NAFLD(T2DM-NAFLD)are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively,in Mongolian medicine.Xike Rixijing Disease maybe develop into Tonglaga Indigestion Disease.Forturnately many Mongolian medicines show efficient treatment of T2DM-NAFLD,such as Agriophyllum squarrosum,Haliyasu(dried powder of camel placenta),Digeda-4(herbs of Lomatogonium carinthiacum,rhizomata of Coptis chinensis,ripe fruits of Gardenia jasminoides,herbs of Dianthus superbus),Guangmingyan Siwei Decoction Powder(Halite,ripe fruits of Terminalia che-bula,rhizomata of Zingiber officinale,fruit clusters of Piper longum),Tonglaga-5(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,flowers of Carthamus tinctorius),Tegexidegeqi(rhizomata of Inula helenium,ripe fruits of Gardenia jasmi-noides,rhizomata of Platycodon grandiflorum,rhizomata of Coptis chinensis,heartwood of Caesalpinia sap-pan),Ligan Shiliu Bawei San(ripe fruits of Punica granatum,barks of Cinnamomum cassia,ripe fruits of Amomum kravanh,fruit clusters of Piper longum,flowers of Carthamus tinctorius,ripe fruits of Amomum tsao-ko,rhizomata of Zingiber officinale),etc.Principles of Mongolian medicine in treating diseases:by balancing"three essences or roots"and"seven elements",strengthening liver and kidney function,trans-porting nutrients to enhance physical strength and disease resistance,and combined with drugs for com-prehensive conditioning treatment.However,their molecular mechanisms remain unclear.In this review,we prospect that Mongolian medicines might be a promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-κB inflammatory pathway via lipid-sensitive nuclear receptors(i.e.,FXR and LXR).

Shuyin Bao;Xiuzhi Wang;Qianqian Ma;Chengxi Wei;Jixing Nan;Wuliji Ao

Institute of Pharmaceutical Chemistry and Pharmacology,Inner Mongolia Minzu University,Tongliao 028000,China;Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System,Tongliao 028000,China;Jilin Key Laboratory for Traditional Chinese Korean Medicine,College of Pharmacy,Yanbian University,Yanji 133002,China;Department of Medicines and Foods,Tongliao Vocational College,Tongliao 028000,China;Research and development center,Inner Mongolia Research Institute of Traditional Mongolian Medicine Engineering Technology,Tongliao 028000,China;Mongolian Medicine R&D National Local Union Engineering Research Center,Inner Mongolia Minzu University,Tongliao 028000,China

中草药（英文版）

[1]Shuyin Bao;Xiuzhi Wang;Qianqian Ma;Chengxi Wei;Jixing Nan;Wuliji Ao-.Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation)[J].中草药（英文版）,2022(03):367-375

steato,Xike,Rixijing,Tonglaga,Indigestion,Forturnately,Haliyasu,Digeda,Lomatogonium,carinthiacum,rhizomata,superbus,Guangmingyan,Siwei,Halite,bula,kravanh,Tegexidegeqi,helenium,jasmi,noides,Platycodon,grandiflorum,heartwood,Ligan,Shiliu,Bawei,essences

Mongolian,treating,type,diabetes,mellitus,combined,nonalcoholic,fatty,liver,via,FXR,LXR,mediated,P2X7R,NLRP3,pathway,activation,Type,T2DM,NAFLD,are,most,problematic,metabolic,diseases,world,encompasses,spectrum,severity,ranging,from,simple,steatohepatitis,NASH,fibrosis,increasing,risk,cirrhosis,hepatocellular,carcinoma,Importantly,closely,linked,obesity,tightly,interrelated,insulin,resistance,called,Disease,respectively,maybe,develop,into,many,medicines,show,efficient,treatment,such,Agriophyllum,squarrosum,dried,powder,camel,placenta,herbs,Coptis,chinensis,ripe,fruits,Gardenia,jasminoides,Dianthus,Decoction,Powder,Terminalia,che,Zingiber,officinale,clusters,Piper,longum,Punica,granatum,barks,Cinnamomum,cassia,Amomum,flowers,Carthamus,tinctorius,Inula,Caesalpinia,sap,pan,San,tsao,ko,etc,Principles,by,balancing,three,roots,seven,elements,strengthening,kidney,function,trans,porting,nutrients,enhance,physical,drugs,prehensive,conditioning,However,their,molecular,mechanisms,remain,unclear,this,review,prospect,that,might,promising,activating,inflammatory,lipid,sensitive,nuclear,receptors

0.427279